Indications for: Captopril/Hydrochlorothiazide


Adult Dosage:

Take 1 hr before meals. As initial therapy: one 25/15 tab daily; adjust at 6 wk intervals. Previously titrated: use same doses as individual components. Usual max 150mg captopril, 50mg hydrochlorothiazide daily.

Children Dosage:

See full labeling.

Captopril/Hydrochlorothiazide Contraindications:

Anuria. Sulfonamide allergy. History of ACEI-associated angioedema.

Boxed Warning:

Fetal toxicity.

Captopril/Hydrochlorothiazide Warnings/Precautions:

Fetal toxicity may develop: discontinue if pregnancy is detected. Renal or hepatic dysfunction. Salt/volume depletion. CHF. Dialysis (esp. high-flux membrane). Aortic stenosis. Diabetes. Gout. Asthma. Postsympathectomy. Surgery. Monitor electrolytes. Monitor WBCs and renal function in renal and collagen vascular disease. Discontinue if neutropenia, agranulocytosis, angioedema or laryngeal edema occurs. Pregnancy (Cat.D in 2nd and 3rd trimesters). Nursing mothers: not recommended.

Captopril/Hydrochlorothiazide Classification:

ACE inhibitor + diuretic.

Captopril/Hydrochlorothiazide Interactions:

Potentiated by antihypertensives. Potentiates tubocurarine. May antagonize sulfonylureas, oral anticoagulants, uricosurics. May be antagonized by NSAIDs, sympathomimetics. May increase digitalis, lithium, insulin, diazoxide toxicity. Hyperkalemia with potassium-sparing diuretics and supplements. Hypokalemia with ACTH, corticosteroids. Orthostatic hypotension may be increased by alcohol, CNS depressants. May interfere with parathyroid, urinary acetone tests.

Adverse Reactions:

Neutropenia, agranulocytosis, proteinuria, nephrotic syndrome, orthostatic hypotension, fluid or electrolyte imbalance, rash, GI upset, dysgeusia, hyperglycemia, hyperuricemia, dizziness, headache, cough, pruritus, angioedema, tachycardia, chest pain, jaundice, blurred vision.


Formerly known under the brand name Capozide.

How Supplied:

Contact supplier.