Cafcit Injection

  • Respiratory stimulants

Cafcit Injection Generic Name & Formulations

General Description

Caffeine citrate 20mg/mL (equivalent to caffeine base 10mg/mL); soln for IV infusion; preservative-free.

Pharmacological Class


How Supplied

Single-use vial (3mL)—1; Oral soln (3mL)—10


Cafcit Injection Indications


Short-term treatment of apnea of prematurity in infants 28 to <33 weeks gestational age.

Cafcit Injection Dosage and Administration


Not applicable.


Use a syringe infusion pump when infusing. Loading dose: 20mg/kg caffeine citrate by IV infusion once (over 30 minutes); then, beginning 24 hours after loading dose: maintenance 5mg/kg caffeine citrate by IV infusion every 24 hours (over 10 minutes). Adjust based on response and serum caffeine levels.

Cafcit Injection Contraindications

Not Applicable

Cafcit Injection Boxed Warnings

Not Applicable

Cafcit Injection Warnings/Precautions


Measure baseline serum caffeine levels in infants previously treated with theophylline (or aminophylline) and in infants born to mothers who consumed caffeine prior to delivery. Serious toxicity may occur with serum caffeine levels >50mg/L. Exclude or treat other causes of apnea. Seizure disorders. Cardiovascular disease. Monitor caffeine levels in impaired renal or hepatic function; adjust dose to avoid toxicity. Monitor serum glucose levels and for necrotizing enterocolitis. Pregnancy (Cat.C).

Cafcit Injection Pharmacokinetics

See Literature

Cafcit Injection Interactions


Avoid concomitant theophylline, aminophylline (increased toxicity). May be potentiated by cimetidine, ketoconazole, others (may need to reduce caffeine dose). May be antagonized by phenobarbital, phenytoin, others (may need to increase caffeine dose). Caution with CYP1A2 substrates, inhibitors, or inducers.

Cafcit Injection Adverse Reactions

Adverse Reactions

CNS stimulation, cardiovascular or GI effects, increased gastric aspirate, feeding intolerance, hypo- or hyperglycemia, hemorrhage, acidosis, sepsis, lung edema, dyspnea, renal effects (eg, diuresis, renal failure), necrotizing enterocolitis.

Cafcit Injection Clinical Trials

See Literature

Cafcit Injection Note

Not Applicable

Cafcit Injection Patient Counseling

See Literature