• Diabetes

Byetta Generic Name & Formulations

General Description

Exenatide 250mcg/mL; soln for SC inj; contains m-cresol and mannitol.

Pharmacological Class

Glucagon-like peptide-1 (GLP-1) receptor agonist.

How Supplied

Prefilled pen (1.2mL, 2.4mL)—1 (60 doses)

Generic Availability


Byetta Indications


Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

Limitations of Use

Not for treating type 1 diabetes. Not studied in patients with a history of pancreatitis. Should not be used with other exenatide-containing products.

Byetta Dosage and Administration


Give by SC inj into thigh, abdomen, or upper arm within 60mins before AM and PM meals (or before the 2 main meals of the day, approx. ≥6hrs apart). Initially 5mcg twice daily; may increase to 10mcg twice daily after 1 month. Moderate renal impairment (CrCl 30–50mL/min): caution when initiating or escalating doses from 5mcg to 10mcg.


Not established.

Byetta Contraindications


History of drug-induced immune-mediated thrombocytopenia from exenatide products.

Byetta Boxed Warnings

Not Applicable

Byetta Warnings/Precautions


Do not reuse or share pens between patients, even if the needle is changed. History of pancreatitis; consider other antidiabetic therapies. Monitor for pancreatitis, drug-induced thrombocytopenia; discontinue if suspected; do not restart if confirmed. Acute gallbladder disease (eg, cholelithiasis, cholecystitis). Perform gallbladder studies and clinical follow-up if cholelithiasis is suspected. History of anaphylaxis or angioedema with another GLP-1 agonist; monitor closely. Severe GI disorders, renal impairment (CrCl <30mL/min), ESRD: not recommended. Renal transplantation. Elderly. Pregnancy. Nursing mothers.

Byetta Pharmacokinetics

See Literature

Byetta Interactions


Increased risk of hypoglycemia with concomitant sulfonylurea, insulin, or other insulin secretagogues; may need lower dose of these. May delay absorption of oral drugs (take these ≥1hr before exenatide). Monitor warfarin.

Byetta Adverse Reactions

Adverse Reactions

GI upset, hypoglycemia, feeling jittery, dizziness, headache, dyspepsia, constipation, asthenia; antibody formation (glycemic response may be attenuated), pancreatitis (may be fatal), hypersensitivity reactions (discontinue if occur), acute renal injury.

Byetta Clinical Trials

See Literature

Byetta Note

Not Applicable

Byetta Patient Counseling

See Literature