Butorphanol Nasal Spray

  • Narcotic analgesics

Butorphanol Nasal Spray Generic Name & Formulations

General Description

Butorphanol tartrate 1mg/spray; nasal spray.

Pharmacological Class

Opioid (agonist-antagonist).

How Supplied

Nasal Spray 2.5mL (8–15 sprays)—Contact supplier.

Butorphanol Nasal Spray Indications


Pain management when opioid analgesia is appropriate.

Butorphanol Nasal Spray Dosage and Administration


≥18 years: initially 1 spray in 1 nostril, repeat after 60–90 minutes if needed (Elderly: 90–120 minutes); may repeat in 3–4 hours. Or, may give 1 spray in each nostril, may repeat after 3–4 hours.


<18 years: not recommended.

Butorphanol Nasal Spray Contraindications

Not Applicable

Butorphanol Nasal Spray Boxed Warnings

Not Applicable

Butorphanol Nasal Spray Warnings/Precautions


Head injury. Increased intracranial pressure. Biliary tract surgery. Respiratory, cardiac, renal, or hepatic dysfunction. MI. Ventricular dysfunction. Coronary insufficiency. Hypertension. May precipitate withdrawal in narcotic addicts. Elderly. Labor & delivery. Pregnancy (Cat.C). Nursing mothers.

Butorphanol Nasal Spray Pharmacokinetics

See Literature

Butorphanol Nasal Spray Interactions


Potentiates CNS depression with alcohol, other CNS depressants. Nasal vasoconstrictors delay onset. May be antagonized by concomitant (within 30 minutes) sumatriptan nasal spray.

Butorphanol Nasal Spray Adverse Reactions

Adverse Reactions

Sedation, dizziness, nasal congestion, insomnia, GI upset, respiratory depression, sweating, hypo- or hypertension, rash, vasodilation, palpitation, tinnitus, respiratory and CNS effects.

Butorphanol Nasal Spray Clinical Trials

See Literature

Butorphanol Nasal Spray Note


Formerly known under the brand name Stadol NS.

Butorphanol Nasal Spray Patient Counseling

See Literature