• Miscellaneous respiratory disorders

Bronchitol Generic Name & Formulations

General Description

Mannitol 40mg; per cap; pwd for oral inhalation; with inhaler.

Pharmacological Class

Sugar alcohol.

How Supplied

Caps—10, 140, 560 (w. inhalers)


Generic Availability


Bronchitol Indications


As add-on maintenance therapy to improve pulmonary function in adults with cystic fibrosis. Use only in those who have passed the Bronchitol Tolerance Test (BTT).

Bronchitol Dosage and Administration


Must perform the BTT and evaluate response prior to prescribing. Administer an orally inhaled, short-acting bronchodilator 5–15mins prior to each dose. 400mg twice daily by oral inhalation (contents of 10 caps administered individually) via the inhaler. Take in the AM and PM (with the later dose at least 2–3hrs before bedtime). Discard inhaler and replace after 7 days of use.


Not established.

Bronchitol Contraindications


Failure to pass the Bronchitol Tolerance Test (BTT).

Bronchitol Boxed Warnings

Not Applicable

Bronchitol Warnings/Precautions


Must be administered under the supervision of a healthcare provider. Have rescue medication and resuscitation equipment readily available. Discontinue immediately if bronchospasm occurs; treat with an inhaled short-acting bronchodilator or as appropriate. History of significant hemoptysis episodes (>60mL) in the previous 3 months: not studied. Renal impairment. Pregnancy. Nursing mothers.

Bronchitol Pharmacokinetics

See Literature

Bronchitol Interactions

Not Applicable

Bronchitol Adverse Reactions

Adverse Reactions

Cough, hemoptysis (discontinue if occurs), oropharyngeal pain, vomiting, bacteria sputum identified, pyrexia, arthralgia; bronchospasm.

Bronchitol Clinical Trials

See Literature

Bronchitol Note

Not Applicable

Bronchitol Patient Counseling

See Literature