Bosulif Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
How Supplied
Manufacturer
Generic Availability
Mechanism of Action
Bosulif Indications
Indications
Bosulif Dosage and Administration
Adult
Children
Administration
Nursing Considerations
Bosulif Contraindications
Not Applicable
Bosulif Boxed Warnings
Not Applicable
Bosulif Warnings/Precautions
Warnings/Precautions
Bosulif Pharmacokinetics
Absorption
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Following administration of a single oral dose of Bosulif 500 mg with food in patients with CML, the median (minimum, maximum) time-to-peak concentration (tmax) was 6.0 (6.0, 6.0) hours. The absolute bioavailability was 34% in healthy subjects.
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Effect of Food:
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When given with a high fat meal in healthy subjects, oral bosutinib Cmax increased 1.8-fold and AUC increased 1.7-fold. The high-fat meal (800-1000 total calories) consisted of approximately 150 protein calories, 250 carbohydrate calories, and 500-600 fat calories.
Distribution
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Mean volume of distribution (SD): 2441 (796) L in healthy subjects; 6080 (1230) L in patients with CML.
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Protein binding is 94% in vitro and 96% ex vivo.
Elimination
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Fecal (91.3%), renal (3.3%).
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Mean half-life (SD): 22.5 (1.7) hours. Mean clearance (SD): 189 (48) L/h.
Bosulif Interactions
Interactions
Bosulif Adverse Reactions
Adverse Reactions
Bosulif Clinical Trials
See Literature
Bosulif Note
Not Applicable
Bosulif Patient Counseling
See Literature
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