• Vaccines

Boostrix Generic Name & Formulations

General Description

Tetanus and reduced diphtheria toxoid, acellular pertussis vaccine (aluminum hydroxide adsorbed); susp for IM inj; preservative-free.

Pharmacological Class


How Supplied

Single-dose vials or prefilled syringes (without needles)—10


Boostrix Indications


Diphtheria, tetanus, and pertussis booster immunization in patients ≥10 years of age. Immunization during the 3rd trimester of pregnancy to prevent pertussis in infants <2 months of age.

Boostrix Dosage and Administration

Adults and Children

Booster immunization: <10yrs: not recommended. ≥10yrs (≥5yrs after last childhood DTwP or DTaP or adult Td vaccine): 0.5mL IM once into deltoid muscle.  Immunization during 3rd trimester of pregnancy: 0.5mL IM once into deltoid muscle.

Boostrix Contraindications


Encephalopathy within 7 days after previous DTaP or DTwP vaccination.

Boostrix Boxed Warnings

Not Applicable

Boostrix Warnings/Precautions


Guillain-Barre syndrome (within 6 weeks) after previous tetanus toxoid vaccine: see full labeling. Progressive or unstable neurologic disorders (eg, cerebrovascular events, acute encephalopathic conditions). Previous Arthus-type hypersensitivity reaction: not recommended until ≥10yrs after prior dose of tetanus toxoid-containing vaccine. Immunosuppressed. Have epinephrine available. Latex allergy. Pregnancy: see full labeling. Nursing mothers.

Boostrix Pharmacokinetics

See Literature

Boostrix Interactions


Concomitant vaccines: see full labeling. Immunosuppressants (eg, radiation, chemotherapy, high-dose steroids): may get suboptimal response.

Boostrix Adverse Reactions

Adverse Reactions

Local reactions (eg, pain, redness, swelling), fever, headache, fatigue, GI upset.

Boostrix Clinical Trials

See Literature

Boostrix Note


Register pregnant patients exposed to Boostrix by calling (888) 452-9622. Report adverse events to VAERS by calling (800) 822-7967.

Boostrix Patient Counseling

See Literature