• Hypotension

Biorphen Generic Name & Formulations

General Description

Phenylephrine HCl 0.1mg/mL; soln for IV inj.

Pharmacological Class


How Supplied

Ampules (5mL)—10

Biorphen Indications


Treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia.

Biorphen Dosage and Administration


Initially 40–100mcg by IV bolus, additional doses may be administered every 1–2 minutes as needed; up to max total dose of 200mcg.


Not established.

Biorphen Contraindications

Not Applicable

Biorphen Boxed Warnings

Not Applicable

Biorphen Warnings/Precautions


Exacerbation of angina (in those with severe arteriosclerosis or history of angina). Heart failure. Pulmonary arterial hypertension. Extensive peripheral vascular disease. Monitor renal function. ESRD. Autonomic dysfunction (eg, spinal cord injury). Avoid extravasation. Elderly. Pregnancy. Nursing mothers.

Biorphen Pharmacokinetics

See Literature

Biorphen Interactions


Potentiated by oxytocic drugs, tricyclic antidepressants, MAOIs, angiotensin, aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot derivatives. Antagonized by alpha-adrenergic antagonists, PDE-5 inhibitors, mixed alpha- and beta-receptor antagonists, calcium channel blockers (eg, nifedipine), benzodiazepines, ACE inhibitors, reserpine, guanfacine.

Biorphen Adverse Reactions

Adverse Reactions

Nausea, vomiting, headache; vasoconstriction, ischemia, severe bradycardia, renal toxicity.

Biorphen Clinical Trials

See Literature

Biorphen Note

Not Applicable

Biorphen Patient Counseling

See Literature