• Helmintic infections

Biltricide Generic Name & Formulations

General Description

Praziquantel 600mg; scored tabs.

Pharmacological Class


How Supplied



Biltricide Indications


Schistosomiasis infection due to all species of schistosoma. Clonorchiasis and opisthorchiasis infection due to the liver flukes, Clonorchis sinensis/Opisthorchis viverrini.

Biltricide Dosage and Administration

Adults and Children

Swallow whole with water during meals. In children <6yrs, may be crushed or disintegrated and mixed with semi-solid food or liquid. <1yr: not established. ≥1yr: Schistosomiasis: 20mg/kg 3 times daily separated by 4–6hrs for 1 day. Clonorchiasis, opisthorchiasis: 25mg/kg 3 times daily separated by 4–6hrs for 1 day.

Biltricide Contraindications


Ocular cysticercosis. Concomitant strong CYP450 inducers (eg, rifampin).

Biltricide Boxed Warnings

Not Applicable

Biltricide Warnings/Precautions


History of epilepsy. Cerebral cysticercosis: hospitalize patient for duration of treatment. Cardiac arrhythmias (monitor). Possible clinical deterioration (paradoxical reactions, serum sickness Jarisch-Herxheimer like reactions) in patients with schistosomiasis. Moderate-to-severe hepatic impairment; monitor. Pregnancy. Nursing mothers.

Biltricide Pharmacokinetics

See Literature

Biltricide Interactions


See Contraindications. Discontinue rifampin 4 weeks before giving praziquantel; may be restarted one day after completing praziquantel treatment. Potentiated by CYP450 inhibitors (eg, cimetidine, ketoconazole, itraconazole, erythromycin), grapefruit juice. Antagonized by CYP450 inducers (eg, phenytoin, phenobarbital, carbamazepine, dexamethasone).

Biltricide Adverse Reactions

Adverse Reactions

Malaise, headache, dizziness, abdominal discomfort with or w/o nausea, fever, urticaria.

Biltricide Clinical Trials

See Literature

Biltricide Note

Not Applicable

Biltricide Patient Counseling

See Literature