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Biltricide Generic Name & Formulations
Legal Class
Rx
General Description
Praziquantel 600mg; scored tabs.
Pharmacological Class
Trematodicide.
How Supplied
Tabs—6
Manufacturer
Biltricide Indications
Indications
Schistosomiasis infection due to all species of schistosoma. Clonorchiasis and opisthorchiasis infection due to the liver flukes, Clonorchis sinensis/Opisthorchis viverrini.
Biltricide Dosage and Administration
Adults and Children
Swallow whole with water during meals. In children <6yrs, may be crushed or disintegrated and mixed with semi-solid food or liquid. <1yr: not established. ≥1yr: Schistosomiasis: 20mg/kg 3 times daily separated by 4–6hrs for 1 day. Clonorchiasis, opisthorchiasis: 25mg/kg 3 times daily separated by 4–6hrs for 1 day.
Biltricide Contraindications
Contraindications
Ocular cysticercosis. Concomitant strong CYP450 inducers (eg, rifampin).
Biltricide Boxed Warnings
Not Applicable
Biltricide Warnings/Precautions
Warnings/Precautions
History of epilepsy. Cerebral cysticercosis: hospitalize patient for duration of treatment. Cardiac arrhythmias (monitor). Possible clinical deterioration (paradoxical reactions, serum sickness Jarisch-Herxheimer like reactions) in patients with schistosomiasis. Moderate-to-severe hepatic impairment; monitor. Pregnancy. Nursing mothers.
Biltricide Pharmacokinetics
See Literature
Biltricide Interactions
Interactions
See Contraindications. Discontinue rifampin 4 weeks before giving praziquantel; may be restarted one day after completing praziquantel treatment. Potentiated by CYP450 inhibitors (eg, cimetidine, ketoconazole, itraconazole, erythromycin), grapefruit juice. Antagonized by CYP450 inducers (eg, phenytoin, phenobarbital, carbamazepine, dexamethasone).
Biltricide Adverse Reactions
Adverse Reactions
Malaise, headache, dizziness, abdominal discomfort with or w/o nausea, fever, urticaria.
Biltricide Clinical Trials
See Literature
Biltricide Note
Not Applicable
Biltricide Patient Counseling
See Literature
