Bicillin L-a

  • Bacterial infections

Bicillin L-a Generic Name & Formulations

General Description

Penicillin G benzathine 600,000 units/mL; susp for deep IM inj; contains parabens.

Pharmacological Class

Penicillinase-sensitive penicillin.

How Supplied

Disposable syringe 600,000 or 1.2 million units/syr (1mL, 2mL)—10 (w. 1 or 1.5 inch needles); Disposable syringe 2.4million units/syr (4mL)—10 (w. 1.5 inch needles)


Bicillin L-a Indications


Susceptible infections, including mild to moderate upper respiratory strep infections, syphilis. Follow-up prophylaxis of rheumatic heart disease, acute glomerulonephritis.

Bicillin L-a Dosage and Administration


Give by deep IM inj into upper outer quadrant of buttock; rotate inj sites. Upper respiratory Group A strep: 1.2 million units once. Syphilis (primary, secondary, latent): 2.4 million units once; (tertiary and neurosyphilis): 2.4 million units every 7 days for 3 doses. Rheumatic heart disease, acute glomerulonephritis: 1.2 million units once per month, or 600,000 units every 2 weeks.


Give by deep IM inj into upper outer quadrant of buttock or midlateral thigh; rotate inj sites. Upper respiratory Group A strep (<60 lbs): 300,000 to 600,000 units once; (>60 lbs): 900,000 units once. Congenital syphilis (<2yrs): 50,000 units/kg once; (≥2yrs): individualize.

Bicillin L-a Contraindications


Avoid intraarterial, intravascular, or intraneural injection.

Bicillin L-a Boxed Warnings

Boxed Warning

Not for IV use. Do not admix with other IV solutions. Reports of inadvertent IV administration has been associated with cardiorespiratory arrest and death.

Bicillin L-a Warnings/Precautions


Not for IV use. Cephalosporin, imipenem, or other allergy: not recommended. Discontinue if severe cutaneous adverse reaction (eg, SJS, TEN, DRESS, AGEP) is suspected; consider alternative therapy. Asthma. Monitor renal and hematopoietic function in prolonged use. Elderly. Pregnancy. Nursing mothers.

Bicillin L-a Pharmacokinetics

See Literature

Bicillin L-a Interactions


Potentiated by probenecid. May cause false (+) glucose test with Clinitest.

Bicillin L-a Adverse Reactions

Adverse Reactions

Rash, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions; severe cutaneous adverse reactions.

Bicillin L-a Clinical Trials

See Literature

Bicillin L-a Note

Not Applicable

Bicillin L-a Patient Counseling

See Literature