Bicillin C-r

  • Bacterial infections

Bicillin C-r Generic Name & Formulations

General Description

Penicillin G benzathine, penicillin G procaine equal amounts; combined penicillin G dose 600,000 units/mL; susp for deep IM inj; contains parabens.

Pharmacological Class

Penicillinase-sensitive penicillin.

How Supplied

C-R disposable syringe 600,000 units/mL (2mL)—10 (w. 1 inch or 1.5 inch needles); C-R 900/300 disposable syringe 1.2 million units (2mL)—10 (w. 1 inch needle)


Bicillin C-r Indications


Susceptible moderately severe infections including respiratory, skin and soft tissue, erysipelas, scarlet fever, otitis media.

Bicillin C-r Dosage and Administration

Adults and Children

Give by deep IM inj into upper, outer buttock (dorsogluteal) or ventrogluteal site; for younger children, midlateral thigh may be preferred. Group A strep: <30lbs: 600,000 units; 30–60lbs: 900,000–1.2 million units; >60lbs: 2.4 million units; all as single dose (may split injections) or may give one-half total dose on day 1 and one-half on day 3. Pneumococcal (except meningitis) children: 600,000 units; adults 1.2 million units; give every 2–3 days until afebrile for 48hrs.

Bicillin C-r Contraindications

Not Applicable

Bicillin C-r Boxed Warnings

Boxed Warning

Not for IV use. Do not admix with other IV solutions. Reports of inadvertent IV administration has been associated with cardiorespiratory arrest and death.

Bicillin C-r Warnings/Precautions


Not for IV use; do not inject into or near an artery or nerve. Risk of femoris necrosis and atrophy with IM injs into the anterolateral thigh; not recommended. History of cephalosporin or significant allergies. Discontinue if severe cutaneous adverse reaction (eg, SJS, TEN, DRESS, AGEP) is suspected; consider alternative therapy. Asthma. Increased risk of methemoglobinemia in G6PD deficiency, congenital/idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6mos; monitor and discontinue if occurs. Monitor renal and hematopoietic function in prolonged use. Discontinue if superinfection develops. Elderly. Pregnancy. Nursing mothers.

Bicillin C-r Pharmacokinetics

See Literature

Bicillin C-r Interactions


Do not admix with other intravenous solutions. Antagonized by concomitant tetracycline; avoid. Potentiated by probenecid. Increased risk of methemoglobinemia with concomitant local anesthetics, acetaminophen, sulfonamides, nitrates, phenytoin, phenobarbital, cyclophosphamide; see full labeling.

Bicillin C-r Adverse Reactions

Adverse Reactions

Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions, methemoglobinemia, C. difficile-associated diarrhea; severe cutaneous adverse reactions.

Bicillin C-r Clinical Trials

See Literature

Bicillin C-r Note

Not Applicable

Bicillin C-r Patient Counseling

See Literature