Bicillin C-r Generic Name & Formulations
Penicillin G benzathine, penicillin G procaine equal amounts; combined penicillin G dose 600,000 units/mL; susp for deep IM inj; contains parabens.
C-R disposable syringe 600,000 units/mL (2mL)—10 (w. 1 inch or 1.5 inch needles); C-R 900/300 disposable syringe 1.2 million units (2mL)—10 (w. 1 inch needle)
Bicillin C-r Indications
Susceptible moderately severe infections including respiratory, skin and soft tissue, erysipelas, scarlet fever, otitis media.
Bicillin C-r Dosage and Administration
Adults and Children
Give by deep IM inj into upper, outer buttock (dorsogluteal) or ventrogluteal site; for younger children, midlateral thigh may be preferred. Group A strep: <30lbs: 600,000 units; 30–60lbs: 900,000–1.2 million units; >60lbs: 2.4 million units; all as single dose (may split injections) or may give one-half total dose on day 1 and one-half on day 3. Pneumococcal (except meningitis) children: 600,000 units; adults 1.2 million units; give every 2–3 days until afebrile for 48hrs.
Bicillin C-r Contraindications
Bicillin C-r Boxed Warnings
Not for IV use. Do not admix with other IV solutions. Reports of inadvertent IV administration has been associated with cardiorespiratory arrest and death.
Bicillin C-r Warnings/Precautions
Not for IV use; do not inject into or near an artery or nerve. Risk of femoris necrosis and atrophy with IM injs into the anterolateral thigh; not recommended. History of cephalosporin or significant allergies. Discontinue if severe cutaneous adverse reaction (eg, SJS, TEN, DRESS, AGEP) is suspected; consider alternative therapy. Asthma. Increased risk of methemoglobinemia in G6PD deficiency, congenital/idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6mos; monitor and discontinue if occurs. Monitor renal and hematopoietic function in prolonged use. Discontinue if superinfection develops. Elderly. Pregnancy. Nursing mothers.
Bicillin C-r Pharmacokinetics
Bicillin C-r Interactions
Do not admix with other intravenous solutions. Antagonized by concomitant tetracycline; avoid. Potentiated by probenecid. Increased risk of methemoglobinemia with concomitant local anesthetics, acetaminophen, sulfonamides, nitrates, phenytoin, phenobarbital, cyclophosphamide; see full labeling.
Bicillin C-r Adverse Reactions
Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions, methemoglobinemia, C. difficile-associated diarrhea; severe cutaneous adverse reactions.
Bicillin C-r Clinical Trials
Bicillin C-r Note
Bicillin C-r Patient Counseling