Bicillin C-r 900/300

  • Bacterial infections

Bicillin C-r 900/300 Generic Name & Formulations

General Description

Penicillin G benzathine 900,000 units, penicillin G procaine 300,000 units; per syringe; susp for deep IM inj; contains parabens.

Pharmacological Class

Penicillinase-sensitive penicillin.

See Also

How Supplied

C-R disposable syringe 600,000 units/mL (2mL)—10 (w. 1 inch or 1.5 inch needles); C-R 900/300 disposable syringe 1.2 million units (2mL)—10 (w. 1 inch needle)


Bicillin C-r 900/300 Indications


Susceptible moderately severe infections including respiratory, skin and soft tissue, erysipelas, scarlet fever, otitis media.

Bicillin C-r 900/300 Dosage and Administration


Use other strengths.


Give by deep IM inj into upper, outer buttock (dorsogluteal) or ventrogluteal site; for younger children, midlateral thigh may be preferred. Group A strep: one inj of 900/300 once. Pneumococcal (except meningitis): one inj of 900/300 every 2–3 days until afebrile for 48hrs.

Bicillin C-r 900/300 Contraindications

Not Applicable

Bicillin C-r 900/300 Boxed Warnings

Boxed Warning

Not for IV use. Do not admix with other IV solutions. Reports of inadvertent IV administration has been associated with cardiorespiratory arrest and death.

Bicillin C-r 900/300 Warnings/Precautions


Not for IV use; do not inject into or near an artery or nerve. Risk of femoris necrosis and atrophy with IM injs into the anterolateral thigh; not recommended. History of cephalosporin or significant allergies. Discontinue if severe cutaneous adverse reaction (eg, SJS, TEN, DRESS, AGEP) is suspected; consider alternative therapy. Asthma. Increased risk of methemoglobinemia in G6PD deficiency, congenital/idiopathic methemoglobinemia, cardiac or pulmonary compromise, infants <6mos; monitor and discontinue if occurs. Monitor renal and hematopoietic function in prolonged use. Discontinue if superinfection develops. Elderly. Pregnancy. Nursing mothers.

Bicillin C-r 900/300 Pharmacokinetics

See Literature

Bicillin C-r 900/300 Interactions


Do not admix with other intravenous solutions. Antagonized by concomitant tetracycline; avoid. Potentiated by probenecid. Increased risk of methemoglobinemia with concomitant local anesthetics, acetaminophen, sulfonamides, nitrates, phenytoin, phenobarbital, cyclophosphamide; see full labeling.

Bicillin C-r 900/300 Adverse Reactions

Adverse Reactions

Rash, drug fever, serum sickness, anaphylaxis, blood dyscrasias, neuropathy, nephropathy, inj site reactions, methemoglobinemia, C. difficile-associated diarrhea; severe cutaneous adverse reactions.

Bicillin C-r 900/300 Clinical Trials

See Literature

Bicillin C-r 900/300 Note

Not Applicable

Bicillin C-r 900/300 Patient Counseling

See Literature