Benztropine Generic Name & Formulations
Benztropine mesylate 0.5mg, 1mg, 2mg; scored tabs.
Mechanism of Action
Benztropine mesylate possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.
Adjunct in Parkinsonism, drug-induced extrapyramidal disorders.
Benztropine Dosage and Administration
Parkinsonism: initially 0.5–1mg at bedtime. May increase by 0.5mg at 5–6 day intervals; max 6mg daily. Extrapyramidal disorders: 1–4mg 1–2 times daily. Acute dystonic reactions: 1–2mg IM or IV.
See Contraindications. Use cautiously in older children.
Children <3yrs old.
Benztropine Boxed Warnings
Tardive dyskinesia: not recommended. Narrow-angle glaucoma. Tachycardia. Psychosis. Prostatic hypertrophy. GI or GU obstruction. Chronically ill. Alcoholics. CNS disease. Exposure to extreme heat. Elderly. Pregnancy.
Renal. Half-life: ~36 hours.
Paralytic ileus, hyperthermia, heat stroke with phenothiazines, tricyclic antidepressants. Antagonizes psychotropics.
Benztropine Adverse Reactions
Anticholinergic and antihistaminic effects, weakness, confusion, anhidrosis, excitement, GI upset, depression, lethargy, heat stroke, dysuria, toxic psychosis, rash.
Benztropine Clinical Trials
Tabs formerly known under the brand name Cogentin.
Benztropine Patient Counseling