Benztropine Injection Generic Name & Formulations
Benztropine mesylate 1mg/mL; soln for IM or IV inj.
Mechanism of Action
Benztropine mesylate possesses both anticholinergic and antihistaminic effects, although only the former have been established as therapeutically significant in the management of parkinsonism.
Benztropine Injection Indications
Adjunct in Parkinsonism, drug-induced extrapyramidal disorders.
Benztropine Injection Dosage and Administration
Parkinsonism: initially 0.5–1mg at bedtime. May increase by 0.5mg at 5–6 day intervals; max 6mg daily. Extrapyramidal disorders: 1–4mg 1–2 times daily. Acute dystonic reactions: 1–2mg IM or IV.
See Contraindications. Use cautiously in older children.
Benztropine Injection Contraindications
Children <3yrs old.
Benztropine Injection Boxed Warnings
Benztropine Injection Warnings/Precautions
Tardive dyskinesia: not recommended. Narrow-angle glaucoma. Tachycardia. Psychosis. Prostatic hypertrophy. GI or GU obstruction. Chronically ill. Alcoholics. CNS disease. Exposure to extreme heat. Elderly. Pregnancy.
Benztropine Injection Pharmacokinetics
Renal. Half-life: ~36 hours.
Benztropine Injection Interactions
Paralytic ileus, hyperthermia, heat stroke with phenothiazines, tricyclic antidepressants. Antagonizes psychotropics.
Benztropine Injection Adverse Reactions
Anticholinergic and antihistaminic effects, weakness, confusion, anhidrosis, excitement, GI upset, depression, lethargy, heat stroke, dysuria, toxic psychosis, rash.
Benztropine Injection Clinical Trials
Benztropine Injection Note
Formerly known under the brand name Cogentin.
Benztropine Injection Patient Counseling