Protozoal infections:

Indications for: Benznidazole

Chagas disease (American Trypanosomiasis) caused by Trypanosoma cruzi.

Adult Dosage:

Not applicable.

Children Dosage:

<2yrs: not established. 2–12yrs: 5–8mg/kg given daily in 2 divided doses (approx. 12hrs apart) for 60 days. Tabs can be made into slurry as an alternative administration method. See full labeling.

Benznidazole Contraindications:

Within 2 weeks of disulfiram use. Concomitant alcohol or propylene glycol-containing products during and for at least 3 days after treatment.

Benznidazole Warnings/Precautions:

Discontinue at first sign of serious cutaneous reactions (eg, AGEP, TEN, erythema multiforme, eosinophilic drug reaction), skin reactions presenting additional signs of systemic involvement (eg, lymphadenopathy, fever, purpura), or if neurological symptoms occur. Hematological manifestations of bone marrow depression: treat under strict medical supervision. Monitor CBC, total and differential leukocyte counts before, during and after therapy. Hepatic or renal impairment. Potential for genotoxicity. Embryo-fetal toxicity. Pregnancy: exclude status prior to initiation. Advise females of reproductive potential to use effective contraception during and for 5 days after the last dose. Nursing mothers: not recommended.

Benznidazole Classification:

Nitroimidazole.

Benznidazole Interactions:

See Contraindications. Psychotic reactions may occur when concomitant disulfiram. A disulfiram-like reaction may occur when concomitant alcohol or propylene glycol-containing products; discontinue these during and for at least 3 days after treatment.

Adverse Reactions:

Abdominal pain, rash, decreased weight, headache, nausea, vomiting, neutropenia, urticaria, pruritus, eosinophilia, decreased appetite; hypersensitivity skin reactions, paresthesia, peripheral neuropathy, infertility (in males).

How Supplied:

Tabs—100

Pricing for Benznidazole

100mg tablet (Qty: 240)
Appx. price $614
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