Benicar Hct

  • Hypertension

Benicar Hct Generic Name & Formulations

General Description

Olmesartan medoxomil, hydrochlorothiazide; 20mg/12.5mg, 40mg/12.5mg, 40mg/25mg; tabs.

Pharmacological Class

Angiotensin II receptor blocker (ARB) + thiazide diuretic.

How Supplied

Tabs—30, 90, 1000


Generic Availability


Benicar Hct Indications


Hypertension (not for initial therapy).

Benicar Hct Dosage and Administration


BP not controlled on olmesartan alone: initially 40/12.5mg once daily. Intolerant to or BP not controlled on HCTZ alone: initially 20/12.5mg once daily. Both: may titrate at 2–4 week intervals up to max 40mg/25mg once daily. May substitute for individually titrated components.


Not established.

Benicar Hct Contraindications


Anuria. Sulfonamide allergy. Concomitant aliskiren in patients with diabetes.

Benicar Hct Boxed Warnings

Boxed Warning

Fetal toxicity.

Benicar Hct Warnings/Precautions


Fetal toxicity may develop; discontinue if pregnancy is detected. Correct salt/volume depletion before starting, or monitor closely. Hepatic impairment. Severe renal impairment (CrCl<30mL/min): not established. Renal artery stenosis. Severe CHF. Asthma. Diabetes. SLE. Gout. Acute myopia. Secondary angle-closure glaucoma. Monitor BP, calcium, potassium, renal function periodically. Possibly less effective in black patients. Elderly. Neonates. Pregnancy (Cat.D). Nursing mothers: not recommended.

Benicar Hct Pharmacokinetics

See Literature

Benicar Hct Interactions


See Contraindications. Hyperkalemia with concomitant other drugs that increase serum potassium levels. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Avoid concomitant aliskiren in renal impairment (CrCl <60mL/min). May be antagonized by, and renal toxicity potentiated by NSAIDs, including COX-2 inhibitors; monitor renal function periodically in elderly and/or volume depleted. Lithium toxicity (monitor). Adjust antidiabetics. ACTH, corticosteroids increase hypokalemia risk. Orthostatic hypotension potentiated by alcohol, other CNS depressants. Potentiates other antihypertensives, skeletal muscle relaxants. Give ≥4hrs before colesevelam HCl dose; ≥4hrs before or 4–6hrs after cholestyramine, colestipol resins.

Benicar Hct Adverse Reactions

Adverse Reactions

Nausea, hyperuricemia, dizziness, upper respiratory infection; orthostatic hypotension, renal impairment, hypersensitivity reactions, electrolyte disturbances, possible sprue-like enteropathy; HCTZ: increased risk for non-melanoma skin cancer.

Benicar Hct Clinical Trials

See Literature

Benicar Hct Note

Not Applicable

Benicar Hct Patient Counseling

See Literature