• Sleep-wake disorders

Belsomra Generic Name & Formulations

General Description

Suvorexant 5mg, 10mg, 15mg, 20mg; tabs.

Pharmacological Class

Orexin receptor antagonist.

How Supplied



Generic Availability


Belsomra Indications


Treatment of insomnia characterized by difficulties with sleep onset and/or sleep maintenance.

Belsomra Dosage and Administration


Use lowest effective dose. Take within 30mins of bedtime if able to get full night’s sleep (≥7hrs) before awakening. 10mg once per night; may increase if ineffective; max 20mg once daily. Concomitant moderate CYP3A inhibitors: 5mg once daily; max 10mg once daily. Effect may be delayed if taken with or soon after a meal.


Not established.

Belsomra Contraindications



Belsomra Boxed Warnings

Not Applicable

Belsomra Warnings/Precautions


Monitor for CNS depression, somnolence; discontinue or reduce dose if daytime somnolence develops. Risk of next-day impairment (including impaired driving). Discontinue immediately if complex sleep behaviors develop. Depression. Monitor for suicidal ideation. Compromised respiratory function (eg, COPD, obstructive sleep apnea). Increased risk of exposure-related effects in obese women. Monitor for worsening insomnia or abnormal thinking and behavioral changes. Reevaluate if unresponsive after 7–10 days of treatment. Severe hepatic impairment: not recommended. Drug or alcohol abusers. Elderly. Pregnancy. Nursing mothers.

Belsomra Pharmacokinetics

See Literature

Belsomra Interactions


Avoid alcohol. Potentiates CNS depression with other CNS depressants (eg, benzodiazepines, opioids, tricyclic antidepressants, alcohol); may need to adjust doses. Concomitant strong CYP3A inhibitors (eg, ketoconazole, itraconazole, posaconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, boceprevir, telaprevir, telithromycin, conivaptan): not recommended. Concomitant moderate CYP3A inhibitors (eg, amprenavir, aprepitant, atazanavir, ciprofloxacin, diltiazem, erythromycin, fluconazole, fosamprenavir, grapefruit juice, imatinib, verapamil): reduce dose (see Adults). May be antagonized by strong CYP3A inducers (eg, rifampin, carbamazepine, phenytoin). Monitor digoxin.

Belsomra Adverse Reactions

Adverse Reactions

Somnolence, headache, dizziness; complex sleep behaviors (eg, sleep-driving), sleep paralysis, hallucinations, cataplexy-like symptoms.

Belsomra Clinical Trials

See Literature

Belsomra Note

Not Applicable

Belsomra Patient Counseling

See Literature