• Bacterial infections

Azactam Generic Name & Formulations

General Description

Aztreonam 1g, 2g; for IM or IV inj after reconstitution; sodium-free.

Pharmacological Class


How Supplied

Single-dose vials (15mL)—10; GALAXY containers (50mL)—24


Azactam Indications


Susceptible bacterial infections, including septicemia, lower respiratory tract, complicated or uncomplicated urinary tract, skin and skin structure, gynecologic, intraabdominal. Surgical adjunct.

Azactam Dosage and Administration


UTI: 500mg–1g every 8–12hrs. Other systemic infections: moderately severe: 1–2g every 8–12hrs; severe: 2g every 6–8hrs. All: max 8g/day. Max 1g/dose by IM. Renal impairment (CrCl 10–30mL/min): ½ of dose after loading dose; CrCl <10mL/min: see full labeling.


<9mos: not established. Not for septicemia or certain skin and skin structure infections; see full labeling. 9mos–16yrs (normal renal function only): urinary tract, lower respiratory tract, intraabdominal, gynecologic infections: mild-to-moderate: 30mg/kg IV every 8hrs; moderate-to-severe: 30mg/kg IV every 6–8hrs; max 120mg/kg/day. May need higher dose in patients with cystic fibrosis.

Azactam Contraindications

Not Applicable

Azactam Boxed Warnings

Not Applicable

Azactam Warnings/Precautions


Penicillin, cephalosporin, carbapenem, or other allergy. Renal or hepatic impairment; monitor during therapy. Elderly. Pregnancy (Cat.B). Nursing mothers; consider temporary formula feedings.

Azactam Pharmacokinetics

See Literature

Azactam Interactions


May potentiate nephrotoxicity of concomitant aminoglycosides (esp. at high doses or prolonged use); monitor renal function. Avoid concomitant β-lactamase-inducing drugs (eg, cefoxitin, imipenem).

Azactam Adverse Reactions

Adverse Reactions

Local reactions (eg, phlebitis, discomfort), GI upset, rash, anaphylaxis, blood dyscrasias, elevated liver enzymes or serum creatinine; C. difficile-associated diarrhea, superinfection; rare: toxic epidermal necrolysis.

Azactam Clinical Trials

See Literature

Azactam Note

Not Applicable

Azactam Patient Counseling

See Literature