• Diabetes

Avandia Generic Name & Formulations

General Description

Rosiglitazone (as maleate) 2mg, 4mg; tabs.

Pharmacological Class


How Supplied

Tabs 2mg—60; 4mg—30


Avandia Indications


Adjunct to diet and exercise in type 2 diabetes. Limitations of use: not for treating type 1 diabetes or diabetic ketoacidosis. Not for use with insulin.

Avandia Dosage and Administration


≥18yrs: Give once daily or in two divided doses (AM & PM). Initially 4mg/day; may increase after 8–12 weeks; max 8mg/day.


<18yrs: not recommended.

Avandia Contraindications


Concomitant metformin in renal impairment. NYHA Class III or IV heart failure.

Avandia Boxed Warnings

Boxed Warning

Congestive heart failure.

Avandia Warnings/Precautions


Symptomatic HF or acute coronary syndromes: not recommended. CHF: NYHA Class I or II: increased risk of cardiovascular events (monitor); discontinue or reduce dose if develops. Edema. Monitor for signs/symptoms of heart failure. Hepatic disease. Do not start therapy in active liver disease or if ALT >2.5xULN. Monitor transaminases at baseline, then periodically. If ALT is mildly elevated (≤2.5xULN), follow-up and monitor closely; discontinue if ALT >3xULN or jaundice occurs. Monitor fasting blood glucose and HbA1c levels periodically. Perform regular eye exams. Resumption of premenopausal ovulation in anovulatory patients may occur (may result in unintended pregnancy). Pregnancy. Nursing mothers.

Avandia Pharmacokinetics

See Literature

Avandia Interactions


Concomitant insulin: not recommended. Potentiated by other CYP2C8 inhibitors (eg, gemfibrozil). Antagonized by CYP2C8 inducers (eg, rifampin). Increased risk of hypoglycemia with concomitant other hypoglycemics; may need to reduce dose.

Avandia Adverse Reactions

Adverse Reactions

Upper respiratory tract infection, injury, headache, edema, weight gain, anemia, changes in serum lipids, macular edema (possible); also women: risk of fracture. See full labeling re: risk of myocardial ischemic events.

Avandia Clinical Trials

See Literature

Avandia Note

Not Applicable

Avandia Patient Counseling

See Literature