Hypertension:

Indications for: AVALIDE

Hypertension.

Adult Dosage:

Take once daily. Not controlled on monotherapy: initially 150/12.5mg, titrate to 300/12.5mg then 300/25mg if needed. Initial therapy: start at 150/12.5mg for 1–2 weeks, then titrate as needed up to max 300mg/25mg. May be substituted for titrated components. Severe renal impairment (CrCl ≤30mL/min): not recommended.

Children Dosage:

Not established.

AVALIDE Contraindications:

Anuria. Sulfonamide allergy. Concomitant aliskiren in patients with diabetes.

Boxed Warning:

Fetal toxicity.

AVALIDE Warnings/Precautions:

Fetal toxicity may develop; discontinue if pregnancy is detected. Intravascular volume- or sodium-depletion. Correct hypovolemia before starting therapy. Hepatic impairment. Severe CHF. Severe renal disease. Renal artery stenosis. Asthma. Postsympathectomy. SLE. Gout. Acute angle-closure glaucoma. Elevated IOP. Acute myopia. Choroidal effusions. Monitor renal function and electrolytes periodically. Elderly. Neonates. Pregnancy: avoid. Nursing mothers: not recommended.

AVALIDE Classification:

Angiotensin II receptor blocker (ARB) + thiazide diuretic.

AVALIDE Interactions:

See Contraindications. Dual inhibition of the renin-angiotensin system with ARBs, ACEIs, or aliskiren may increase risk of hypotension, hyperkalemia, renal function changes; monitor closely. Concomitant aliskiren in renal impairment (CrCl <60mL/min): not recommended. Hyperkalemia with K+ supplements, K+ sparing diuretics, K+ containing salt substitutes. Orthostatic hypotension with alcohol, other CNS depressants. Hypokalemia with corticosteroids, ACTH. Potentiates other antihypertensives. May potentiate muscle relaxants (eg, curare derivatives). May be antagonized by, and renal toxicity potentiated by NSAIDs, including COX-2 inhibitors; monitor. Antagonizes norepinephrine. Adjust antihyperglycemics. Separate dosing by ≥4hrs before or 4–6hrs after cholestyramine or colestipol resins. May increase lithium toxicity. Risk of hyponatremia with carbamazepine (monitor). May interfere with parathyroid tests.

Adverse Reactions:

Dizziness, fatigue, musculoskeletal pain, GI upset; renal dysfunction, electrolyte and metabolic disturbances; HCTZ: increased risk for non-melanoma skin cancer.

Generic Drug Availability:

YES

How Supplied:

Tabs—30

Pricing for AVALIDE

300mg/12.5mg tablet (Qty: 90)
Appx. price $43
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