• Mood disorders

Auvelity Generic Name & Formulations

General Description

Dextromethorphan HBr 45mg, bupropion HCl 105mg; ext-rel tabs.

Pharmacological Class

Uncompetitive NMDA receptor antagonist and sigma-1 receptor agonist + aminoketone.

How Supplied


Generic Availability


Auvelity Indications


Major depressive disorder (MDD).

Auvelity Dosage and Administration


Swallow whole. ≥18yrs: initially 1 tab once daily in the AM for 3 days, then increase to 1 tab twice daily (given at least 8hrs apart). Max 2 doses daily. Moderate renal impairment (eGFR 30–59mL/min/1.73m2), concomitant strong CYP2D6 inhibitors, poor CYP2D6 metabolizers: reduce to 1 tab once daily in the AM.


<18yrs: not established.

Auvelity Contraindications


Seizure disorders. Bulimia. Anorexia nervosa. Undergoing abrupt discontinuation of alcohol, benzodiazepines, barbiturates, or antiepileptics. During or within 14 days of discontinuing MAOIs. Concomitant linezolid or IV methylene blue.

Auvelity Boxed Warnings

Boxed Warning

Suicidal thoughts and behavior.

Auvelity Warnings/Precautions


Increased risk of suicidal thinking and behavior in children, adolescents, and young adults; monitor all patients closely for clinical worsening and emergence of suicidal thoughts and behaviors (esp. during the initial few months and at times of dosage changes). Consider alternative regimen including discontinuing treatment if depression worsens or if suicidal thoughts/behaviors occur. Increased risk of seizure with severe head injury, arteriovenous malformation, CNS tumor or CNS infection, severe stroke, metabolic disorders. Discontinue and do not restart treatment if seizure occurs. Risk of dose-related neuropsychiatric reactions (eg, delusions, hallucinations, psychosis, concentration disturbance, paranoia, confusion). Angle-closure glaucoma. Avoid use in those with untreated anatomically narrow angles. Monitor BP prior to initiation and periodically during treatment. Screen for a history of bipolar disorder, mania, or hypomania. Screen for other medications containing bupropion or dextromethorphan. Severe renal (eGFR 15–29mL/min/1.73m2) or hepatic (Child-Pugh C) impairment: not recommended. Embryo-fetal toxicity. Use alternative treatment for females who are planning to become pregnant. Pregnancy: not recommended; discontinue if occurs during treatment. Nursing mothers: not recommended (during and for 5 days after the last dose).

Auvelity Pharmacokinetics

See Literature

Auvelity Interactions


See Contraindications. Increased risk of hypertensive crisis and serotonin syndrome during or within 14 days of discontinuing MAOIs (eg, linezolid or IV methylene blue). Increased risk of serotonin syndrome with other serotonergic drugs; discontinue Auvelity and/or concomitant drug if occurs. Caution with drugs that lower seizure threshold (eg, bupropion products, antipsychotics, tricyclic antidepressants, theophylline, systemic corticosteroids, CNS stimulants) or factors that lower seizure threshold (eg, opiate or cocaine addiction, excessive use of alcohol or sedative/hypnotics). Potentiated by strong CYP2D6 inhibitors; monitor and adjust dose. Antagonized by strong CYP2B6 inducers; avoid. May potentiate CYP2D6 substrates; consider decreasing dose of substrates esp. for drugs with a narrow therapeutic index. May antagonize drugs that require metabolic activation by CYP2D6; consider increasing the dose of these drugs. May antagonize digoxin; monitor. Caution with dopaminergic drugs (eg, levodopa, amantadine). Avoid or minimize consumption of alcohol during treatment. May cause false (+) urine immunoassay test results for amphetamine.

Auvelity Adverse Reactions

Adverse Reactions

Dizziness, headache, diarrhea, somnolence, dry mouth, sexual dysfunction, hyperhidrosis; hypertension.

Auvelity Clinical Trials

See Literature

Auvelity Note

Not Applicable

Auvelity Patient Counseling

See Literature