Bacterial infections:

Indications for AUGMENTIN ES-600 SUSPENSION:

Susceptible recurrent or persistent acute otitis media (see full labeling).

Adult:

Not recommended.

Children:

Take with food. Base dose on amoxicillin component. Due to clavulanic acid component, ES-600 is not interchangable with other susp formulations. <3months: not recommended. ≥3months (<40kg): 90mg/kg per day in 2 divided doses every 12 hours for 10 days. ≥40kg: not recommended.

Contraindications:

History of Augmentin-associated cholestatic jaundice/hepatic dysfunction. XR: Severe renal impairment (CrCl <30mL/min) or hemodialysis.

Warnings/Precautions:

Cephalosporin, imipenem, or other allergy: not recommended. Monitor blood, renal, and hepatic function in long-term use. Hepatic dysfunction. Mononucleosis. Elderly (consider monitoring renal function). Labor & delivery. Pregnancy (Cat.B). Nursing mothers.

Pharmacologic Class:

Broad-spectrum penicillin + β-lactamase inhibitor.

Interactions:

May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Probenecid potentiates amoxicillin. May potentiate oral anticoagulants (monitor). May antagonize oral contraceptives.

Adverse Reactions:

Diarrhea, nausea, abdominal pain, rash, urticaria, vomiting, vaginitis; anaphylaxis.

How Supplied:

XR tabs—28, 40; Tabs 250mg—30; Tabs 500mg, 875mg—20; Susp 125mg/5mL, 250mg/5mL—75mL, 100mL, 150mL; Susp 200mg/5mL, 400mg/5mL—50mL, 75mL, 100mL; Chew tabs 125mg, 250mg—30; Chew tabs 200mg, 400mg—20; Susp ES-600 600mg/5mL—50mL, 75mL, 100mL, 125mL, 150mL, 200mL