• Thromboembolic disorders

Aspirin/dipyridamole Generic Name & Formulations

General Description

Aspirin 25mg (immediate-release), dipyridamole 200mg (extended-release); caps.

Pharmacological Class

Combination antiplatelet.

How Supplied

Contact supplier

Aspirin/dipyridamole Indications


To reduce the risk of stroke in patients who have had transient ischemia of the brain or completed ischemic stroke due to thrombosis.

Aspirin/dipyridamole Dosage and Administration


Swallow whole. 1 cap twice daily, one in the morning and one in the evening. Alternative regimen in case of intolerable headaches: switch to 1 cap at bedtime and low-dose aspirin in AM; return to usual regimen as soon as possible, usually within 1 week.


Not recommended.

Aspirin/dipyridamole Contraindications


NSAID allergy. Patients with the syndrome of asthma, rhinitis, and nasal polyps. Viral infection in children/teens (risk of Reye syndrome).

Aspirin/dipyridamole Boxed Warnings

Not Applicable

Aspirin/dipyridamole Warnings/Precautions


Not interchangeable with individual components of aspirin and dipyridamole. Increased risk of bleeding, including GI bleed. History of active peptic ulcer, severe hepatic or renal dysfunction (GFR <10mL/min); avoid. Coronary artery disease. Pre-existing hypotension. Chronic, heavy alcohol use. Labor & delivery. Pregnancy. Nursing mothers.

Aspirin/dipyridamole Pharmacokinetics

See Literature

Aspirin/dipyridamole Interactions


Increased risk of bleeding with anticoagulants, antiplatelets, heparin, anagrelide, fibrinolytic therapy, alcohol, chronic NSAID use. Potentiates adenosine, acetazolamide, methotrexate, oral hypoglycemics. May antagonize ACE inhibitors, β-blockers, diuretics, cholinesterase inhibitors, uricosurics. May increase risk of renal dysfunction with NSAIDs. Monitor phenytoin, valproic acid, other anticonvulsants. Interrupt aspirin/dipyridamole dosing for 48hrs prior to stress testing using IV dipyridamole or other adenosinergic agents.

Aspirin/dipyridamole Adverse Reactions

Adverse Reactions

Headache, dyspepsia, abdominal pain, nausea, diarrhea; bleeding risk, increased liver enzymes, hepatic failure.

Aspirin/dipyridamole Clinical Trials

See Literature

Aspirin/dipyridamole Note


Formerly known under the brand name Aggrenox.

Aspirin/dipyridamole Patient Counseling

See Literature