• Leukemias, lymphomas, and other hematologic cancers

Asparlas Generic Name & Formulations

General Description

Calaspargase pegol-mknl 750 Units/mL; soln for IV infusion after dilution; preservative-free.

Pharmacological Class

Asparagine-specific enzyme.

How Supplied

Single-dose vial (5mL)—1

Generic Availability


Asparlas Indications


Treatment of acute lymphoblastic leukemia as a component of a multi-agent chemotherapeutic regimen.

Asparlas Dosage and Administration

Adults and Children

<1month: not established. Premedicate with acetaminophen, H1 receptor blocker (eg, diphenhydramine), and H2 receptor blocker (eg, famotidine) 30–60mins prior to administration. 1month–21yrs: Give by IV infusion over 1hr. 2500 Units/m2 no more frequently than every 21 days. Dose modifications: see full labeling.

Asparlas Contraindications


History of serious thrombosis, pancreatitis, or hemorrhagic events with prior L-asparaginase therapy. Severe hepatic impairment.

Asparlas Boxed Warnings

Not Applicable

Asparlas Warnings/Precautions


Have resuscitation equipment available and observe patient for 1hr post-dose. Assess serum amylase and/or lipase levels. Discontinue if serious hypersensitivity reactions, thrombotic events, or pancreatitis occur. Evaluate for hemorrhage with coagulation parameters. Evaluate LFTs at least weekly, during and for ≥6 weeks after last dose. Discontinue if serious hepatotoxicity occurs. Pregnancy: exclude status prior to initiation. Advise females of reproductive potential to use effective non-hormonal contraception during and for ≥3 months after the last dose. Nursing mothers: not recommended (during and for 3 months after the last dose).

Asparlas Pharmacokinetics

See Literature

Asparlas Interactions


Antagonizes hormonal contraceptives.

Asparlas Adverse Reactions

Adverse Reactions

Elevated transaminases, increased bilirubin, pancreatitis, abnormal clotting, diarrhea, hypersensitivity, embolic/thrombotic events, sepsis, dyspnea, hemorrhages.

Asparlas Clinical Trials

See Literature

Asparlas Note

Not Applicable

Asparlas Patient Counseling

See Literature