Arthrotec 75 Generic Name & Formulations
Legal Class
General Description
Pharmacological Class
See Also
How Supplied
Manufacturer
Generic Availability
Arthrotec 75 Indications
Indications
Arthrotec 75 Dosage and Administration
Adult
Children
Renal Impairment
Diclofenac and misoprostol are primarily excreted by the kidney. Prior to initiating Arthrotec, correct volume status in dehydrated and hypovolemic patients. Monitor renal function, especially with concomitant ACE inhibitors and ARBs and in patients with hepatic impairment. Avoid use of Arthrotec in patients with advanced renal disease unless the benefits outweigh the risk of worsening renal function; monitor.
Other Modifications
Women of childbearing potential
- Advise patients of the abortifacient property.
- Verify pregnancy status within 2 weeks prior to initiating Arthrotec.
- Use effective contraception.
Arthrotec may be prescribed to women of childbearing potential if the patient:
- Has had a negative serum pregnancy test within 2 weeks prior to beginning therapy.
- Is capable of complying with effective contraceptive measures.
- Has received both oral and written warnings of the hazards of misoprostol, the risk of possible contraception failure, and the danger to other women of childbearing potential should the drug be taken by mistake.
- Will begin Arthrotec only on the second or third day of the next normal menstrual period.
Diclofenac may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women. Consider withdrawal of NSAIDs in women who have difficulties conceiving or who are undergoing investigation of infertility.
Arthrotec 75 Contraindications
Contraindications
Arthrotec 75 Boxed Warnings
Boxed Warning
Arthrotec 75 Warnings/Precautions
Warnings/Precautions
Arthrotec 75 Pharmacokinetics
Absorption
Diclofenac: Peak plasma levels achieved in 2 hours
Misoprostol: Max plasma concentration in ~20 minutes
Distribution
Diclofenac: 99% protein bound
Misoprostol: <90% protein bound
Elimination
Diclofenac: renal (65%), biliary (35%); half-life: ~2 hours
Misoprostol: renal (70%); half-life: ~30 minutes
Arthrotec 75 Interactions
Interactions
Arthrotec 75 Adverse Reactions
Adverse Reactions
Arthrotec 75 Clinical Trials
Arthrotec 75 Note
Not Applicable
Arthrotec 75 Patient Counseling
Cost Savings Program
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