Artesunate For Injection

  • Malaria

Artesunate For Injection Generic Name & Formulations

General Description

Artesunate 110mg; per vial; pwd for IV inj after reconstitution.

Pharmacological Class


How Supplied

Single-dose vial—1, 4 (w. diluent)


Generic Availability


Artesunate For Injection Indications


Initial treatment of severe malaria.

Limitations of Use

Not for treating the hypnozoite liver stage forms of Plasmodium and therefore not prevent relapses of malaria due to Plasmodium vivax or Plasmodium ovale.

Artesunate For Injection Dosage and Administration

Adults and Children

<6months: not established. Give by slow IV bolus inj over 1–2mins. ≥6months: 2.4mg/kg at 0hr, 12hrs, and 24hrs, and thereafter given once daily until able to tolerate oral antimalarial therapy. Complete treatment course with an appropriate oral antimalarial regimen (eg, an 8-aminoquinoline).

Artesunate For Injection Contraindications

Not Applicable

Artesunate For Injection Boxed Warnings

Not Applicable

Artesunate For Injection Warnings/Precautions


Monitor for post-treatment hemolytic anemia for 4 weeks. Consider discontinuation if hypersensitivity reactions occur; use alternative treatment. Pregnancy. Nursing mothers.

Artesunate For Injection Pharmacokinetics

See Literature

Artesunate For Injection Interactions


May be potentiated by strong UGT inhibitors (eg, axitinib, vandetanib, imatinib, diclofenac); monitor. May be antagonized by ritonavir, nevirapine, or strong UGT inducers (eg, rifampin, carbamazepine, phenytoin); monitor for possible reduced efficacy if used concomitantly.

Artesunate For Injection Adverse Reactions

Adverse Reactions

Acute renal failure requiring dialysis, hemoglobinuria, jaundice, anemia, increased transaminase, thrombocytopenia, hyperbilirubinemia, leukocytosis, acute respiratory distress syndrome, lymphopenia, neutropenia.

Artesunate For Injection Clinical Trials

See Literature

Artesunate For Injection Note

Not Applicable

Artesunate For Injection Patient Counseling

See Literature