Aricept Generic Name & Formulations
Donepezil HCl 5mg, 10mg, 23mg; tabs.
Reversible acetylcholinesterase inhibitor (piperidine deriv).
Tabs 5mg, 10mg—30, 90; 23mg—30; ODT—contact supplier
Aricept Dosage and Administration
Tabs: Swallow whole with water. ODT: dissolve on tongue, follow with water. Mild-to-moderate: Initially 5mg daily at bedtime, may increase to max 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-to-severe: initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; may further increase to max 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.
Aricept Boxed Warnings
Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GU obstruction. Body weight <55kg. Pregnancy. Nursing mothers.
Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.
Aricept Adverse Reactions
Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).
Aricept Clinical Trials
Aricept Patient Counseling