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Aricept Generic Name & Formulations
Legal Class
Rx
General Description
Donepezil HCl 5mg, 10mg, 23mg; tabs.
Pharmacological Class
Reversible acetylcholinesterase inhibitor (piperidine deriv).
See Also
How Supplied
Tabs 5mg, 10mg—30, 90; 23mg—30; ODT—contact supplier
Manufacturer
Aricept Indications
Indications
Alzheimer's dementia.
Aricept Dosage and Administration
Adult
Tabs: Swallow whole with water. ODT: dissolve on tongue, follow with water. Mild-to-moderate: Initially 5mg daily at bedtime, may increase to max 10mg daily after 4–6 weeks; usual dose: 5mg or 10mg once daily. Moderate-to-severe: initially 5mg daily at bedtime, may increase to 10mg daily after 4–6 weeks; may further increase to max 23mg daily after 3 months; usual dose: 10mg or 23mg once daily.
Children
Not established.
Aricept Contraindications
Not Applicable
Aricept Boxed Warnings
Not Applicable
Aricept Warnings/Precautions
Warnings/Precautions
Cardiac conduction conditions. Peptic ulcer. Monitor for GI bleeding. Seizures. Asthma or COPD. GU obstruction. Body weight <55kg. Pregnancy. Nursing mothers.
Aricept Pharmacokinetics
See Literature
Aricept Interactions
Interactions
Drugs that affect CYP2D6 and CYP3A4 may affect rate of elimination. Antagonizes anticholinergics. May potentiate succinylcholine-type muscle relaxants, other cholinesterase inhibitors, cholinergic agonists (eg, bethanecol). Concomitant NSAIDs may increase risk of GI bleed.
Aricept Adverse Reactions
Adverse Reactions
Nausea, diarrhea, vomiting, insomnia, muscle cramps, fatigue, anorexia, weight loss (esp. using 23mg/day dose).
Aricept Clinical Trials
See Literature
Aricept Note
Not Applicable
Aricept Patient Counseling
See Literature
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