• Miscellaneous hematological agents

Argatroban Generic Name & Formulations

General Description

Argatroban 250mg/2.5mL; soln for IV infusion after dilution.

Pharmacological Class

Direct thrombin inhibitor.

How Supplied

Single-use vial—1


Generic Availability


Argatroban Indications


Prophylaxis and treatment of thrombosis in adults with heparin-induced thrombocytopenia (HIT). Anticoagulation in adults with or at risk of HIT undergoing percutaneous coronary intervention (PCI).

Argatroban Dosage and Administration


Give by IV infusion. HIT: discontinue heparin and obtain baseline aPTT. Initially 2mcg/kg/min; check aPTT 2hrs after starting; titrate to 1.5–3x baseline aPTT (max 100secs); max 10mcg/kg/min. PCI: give 350mcg/kg bolus by large bore IV line over 3–5mins, then initiate infusion of 25mcg/kg/min. Check ACT 5–10mins after bolus; titrate based on activated clotting time (ACT) to therapeutic ACT of 300–450secs (see full labeling). Hepatic impairment: reduce dose and titrate carefully; see full labeling. Conversion to oral anticoagulants: see full labeling.


Not established.

Argatroban Contraindications


Major bleeding.

Argatroban Boxed Warnings

Not Applicable

Argatroban Warnings/Precautions


Increased bleeding risk (eg, severe hypertension, recent lumbar puncture, spinal anesthesia, major surgery, bleeding disorders, GI lesions). Hepatic impairment. PCI: avoid high doses in significant hepatic disease or AST/ALT ≥3x ULN. Labor & delivery. Pregnancy. Nursing mothers.

Argatroban Pharmacokinetics

See Literature

Argatroban Interactions


Increased risk of bleeding with concomitant thrombolytics, warfarin, heparin, antiplatelets, GP IIb/IIIa blockers.

Argatroban Adverse Reactions

Adverse Reactions

Bleeding, dyspnea, hypotension, fever, diarrhea, sepsis, cardiac arrest, chest pain, back pain, nausea, vomiting, headache.

Argatroban Clinical Trials

See Literature

Argatroban Note

Not Applicable

Argatroban Patient Counseling

See Literature