• Malaria

Arakoda Generic Name & Formulations

General Description

Tafenoquine 100mg; tabs.

Pharmacological Class


How Supplied


Generic Availability


Arakoda Indications


Malaria prophylaxis.

Arakoda Dosage and Administration


Swallow whole. Take with food. ≥18yrs: initially 200mg once daily starting 3 days before travel, then 200mg once weekly starting 7 days after last loading dose while in endemic area, then 200mg taken once, 7 days after last maintenance dose.


<18yrs: not established.

Arakoda Contraindications


G6PD deficiency or unknown status. Nursing mothers when infant is G6PD deficient or status unknown. History of or current psychotic disorders.

Arakoda Boxed Warnings

Not Applicable

Arakoda Warnings/Precautions


Must test for G6PD deficiency prior to initiation. Monitor for hemolysis; discontinue if occurs. NADH-dependent methemoglobin reductase deficiency; monitor and discontinue if signs of methemoglobinemia occur. Consider discontinuing if psychotic symptoms (eg, hallucinations, delusions, disorganized thinking/behavior) occur. Discontinue if hypersensitivity reactions occur. Renal or hepatic impairment: monitor. Exclude pregnancy status prior to initiation. Pregnancy: not recommended; if detected during therapy, discontinue and switch to alternatives. Advise females of reproductive potential to use effective contraception during and for 3 months after last dose. Nursing mothers: not recommended (during and for 3 months after last dose) in G6PD-deficient infant or status unknown.

Arakoda Pharmacokinetics

See Literature

Arakoda Interactions


Avoid concomitant OCT2 and MATE substrates (eg, dofetilide, metformin); if unavoidable, monitor and consider dose reduction of substrate if needed.

Arakoda Adverse Reactions

Adverse Reactions

Headache, dizziness, back pain, diarrhea, nausea, vomiting, increased ALT, motion sickness, insomnia, depression, abnormal dreams, anxiety; hemolytic anemia, methemoglobinemia, psychiatric effects, hypersensitivity reactions.

Arakoda Clinical Trials

See Literature

Arakoda Note

Not Applicable

Arakoda Patient Counseling

See Literature