Aptensio Xr Generic Name & Formulations
Methylphenidate HCl 10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg; ext-rel caps.
Aptensio Xr Indications
Attention deficit hyperactivity disorder.
Limitations of Use
Pediatrics <6yrs: experienced higher rates of adverse reactions (esp. weight loss).
Aptensio Xr Dosage and Administration
Adults and Children
Individualize. Swallow whole or may open capsule and sprinkle contents onto applesauce. <6yrs: not established. ≥6yrs: 10mg once daily in the AM. May titrate dose in weekly increments of 10mg/day. Max 60mg/day. Discontinue if no improvement after dose adjustment over a 1-month period.
Aptensio Xr Contraindications
During or within 14 days of MAOIs.
Aptensio Xr Boxed Warnings
Abuse and dependence.
Aptensio Xr Warnings/Precautions
High potential for abuse and dependence; monitor. Increased risk of sudden death, stroke, and MI; assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Peripheral vasculopathy including Raynaud's phenomenon; monitor for digital changes. Monitor growth (in children), BP, HR. Reduce dose or discontinue if paradoxical aggravation of symptoms occurs. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.
Aptensio Xr Pharmacokinetics
Aptensio Xr Interactions
See Contraindications. Hypertensive crisis with concomitant MAOIs. Risk of serotonin syndrome with serotonergic drugs. May antagonize antihypertensive drugs; monitor BP and adjust dose of antihypertensives as needed. Concomitant use with risperidone may increase risk of extrapyramidal symptoms; monitor.
Aptensio Xr Adverse Reactions
Headache, insomnia, abdominal pain, decreased appetite, nausea, vomiting, dizziness; hypertension, tachycardia, priapism.
Aptensio Xr Clinical Trials
Aptensio Xr Note
Aptensio Xr Patient Counseling