Aptensio Xr

  • ADHD

Aptensio Xr Generic Name & Formulations

General Description

Methylphenidate HCl 10mg, 15mg, 20mg, 30mg, 40mg, 50mg, 60mg; ext-rel caps.

Pharmacological Class

CNS stimulant.

How Supplied

Ext-rel caps—90


Generic Availability


Aptensio Xr Indications


Attention deficit hyperactivity disorder.

Limitations of Use

Pediatrics <6yrs: experienced higher rates of adverse reactions (esp. weight loss).

Aptensio Xr Dosage and Administration

Adults and Children

Individualize. Swallow whole or may open capsule and sprinkle contents onto applesauce. <6yrs: not established. ≥6yrs: 10mg once daily in the AM. May titrate dose in weekly increments of 10mg/day. Max 60mg/day. Discontinue if no improvement after dose adjustment over a 1-month period.

Aptensio Xr Contraindications


During or within 14 days of MAOIs.

Aptensio Xr Boxed Warnings

Boxed Warning

Abuse and dependence.

Aptensio Xr Warnings/Precautions


High potential for abuse and dependence; monitor. Increased risk of sudden death, stroke, and MI; assess for presence of cardiac disease before initiating. Avoid in known structural cardiac abnormalities, cardiomyopathy, serious arrhythmias, coronary artery disease, and other cardiac problems. Pre-existing psychotic disorder. Bipolar disorder. Screen for risk factors of developing a manic episode prior to initiation. Consider discontinuing if new psychotic/manic symptoms occur. Peripheral vasculopathy including Raynaud's phenomenon; monitor for digital changes. Monitor growth (in children), BP, HR. Reduce dose or discontinue if paradoxical aggravation of symptoms occurs. Write ℞ for smallest practical amount. Reevaluate periodically. Pregnancy. Nursing mothers: monitor infants.

Aptensio Xr Pharmacokinetics

See Literature

Aptensio Xr Interactions


See Contraindications. Hypertensive crisis with concomitant MAOIs. Risk of serotonin syndrome with serotonergic drugs. May antagonize antihypertensive drugs; monitor BP and adjust dose of antihypertensives as needed. Concomitant use with risperidone may increase risk of extrapyramidal symptoms; monitor.

Aptensio Xr Adverse Reactions

Adverse Reactions

Headache, insomnia, abdominal pain, decreased appetite, nausea, vomiting, dizziness; hypertension, tachycardia, priapism.

Aptensio Xr Clinical Trials

See Literature

Aptensio Xr Note

Not Applicable

Aptensio Xr Patient Counseling

See Literature