Colorectal disorders:

Indications for APRISO:

Maintenance of remission of ulcerative colitis (UC) in adults.


Swallow whole. 1.5g once daily in the AM.


Not established.


Sulfasalazine allergy. Discontinue if acute intolerance syndrome is suspected. Conditions predisposing to myocarditis or pericarditis. Atopic dermatitis or eczema: may have more severe photosensitivity reactions. Nephrolithiasis. Ensure adequate hydration. Phenylketonuria. Renal or hepatic impairment. Monitor renal function prior to and periodically during therapy. Elderly (monitor CBCs, platelets). Pregnancy. Nursing mothers: monitor infants.

Pharmacologic Class:



Avoid concomitant antacids. Increased toxicity with nephrotoxic drugs (eg, NSAIDs). Increased risk for blood disorders, bone marrow failure, and associated complications with azathioprine or 6-mercaptopurine and/or other drugs known to cause myelotoxicity. May cause elevated test results when measuring urinary normetanephrine.

Adverse Reactions:

Headache, diarrhea, upper abdominal pain, nausea, nasopharyngitis; renal impairment, hypersensitivity reactions, mesalamine-induced acute intolerance syndrome (eg, cramping, abdominal pain, bloody diarrhea, fever, headache, rash); discontinue if occurs.

Generic Availability:


How Supplied:


Pricing for APRISO

0.375g capsule (Qty: 120)
Appx. price $508