Apraclonidine 0.5%

  • Glaucoma

Apraclonidine 0.5% Generic Name & Formulations

General Description

Apraclonidine (as HCl) 0.5%; oph soln; contains benzalkonium chloride.

Pharmacological Class

Alpha-2 agonist.

See Also

How Supplied

Soln 0.5%—contact supplier; 1% (0.1mL)—2

Apraclonidine 0.5% Indications


Short-term adjunctive therapy to reduce elevated IOP.

Apraclonidine 0.5% Dosage and Administration


Remove contact lenses; may reinsert 15min after instillation. 1–2 drops into affected eye(s) 3 times daily. Allow at least 5mins between instillation of other oph drugs.


Not established.

Apraclonidine 0.5% Contraindications


Clonidine allergy. Concomitant MAOIs.

Apraclonidine 0.5% Boxed Warnings

Not Applicable

Apraclonidine 0.5% Warnings/Precautions


Monitor visual fields. Severe uncontrolled cardiovascular disease, hypertension, coronary insufficiency. Recent myocardial infarction. Cerebrovascular disease. Raynaud's disease. Thromboangiitis obliterans. History of vasovagal attack. Discontinue if ocular allergic-like reactions occur. Renal or hepatic impairment: closely monitor cardiovascular parameters. Depression. May mask hypoglycemia. Pregnancy. Nursing mothers (1% soln: discontinue nursing temporarily for 1 day of use).

Apraclonidine 0.5% Pharmacokinetics

See Literature

Apraclonidine 0.5% Interactions


See Contraindications. May potentiate CNS depressants (eg, alcohol, barbiturates, opiates, sedatives, anesthetics). Caution with TCAs, β-blockers, antihypertensives, cardiac glycosides, others (eg, clonidine). Concomitant CV drugs: monitor HR, BP periodically.

Apraclonidine 0.5% Adverse Reactions

Adverse Reactions

Hyperemia, pruritus, dry mouth, itching, discomfort, tearing, dizziness, solmnolence, lid edema, blurred vision, foreign body sensation, dry eye, conjunctivitis, discharge, blanching; tachyphylaxis may develop after 1 month; also in post-laser surgery: upper lid elevation, inflammation, nasal decongestion, mydriasis, irregular HR.

Apraclonidine 0.5% Clinical Trials

See Literature

Apraclonidine 0.5% Note

Not Applicable

Apraclonidine 0.5% Patient Counseling

See Literature