Bacterial infections:

Indications for ANTHIM:

Treatment of inhalational anthrax in combination with appropriate antibacterial drugs. Prophylaxis of inhalational anthrax when alternative therapies are not available or are not appropriate.

Limitations of Use:

Only use for prophylaxis when its benefit of anthrax prevention outweighs risk of hypersensitivity and anaphylaxis. Has no direct antibacterial activity. Does not cross the blood-brain barrier. Does not prevent or treat meningitis. Pediatrics: safety and pharmacokinetics were not studied.

Adult Dosage:

See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. >40kg: 16mg/kg.

Children Dosage:

See full labeling. Premedicate with diphenhydramine prior to infusion. Give as IV infusion over 90mins. ≤15kg: 32mg/kg; >15–40kg: 24mg/kg; >40kg: use adult dose.

Boxed Warning:

Hypersensitivity. Anaphylaxis.

ANTHIM Warnings/Precautions:

Have trained personnel and medical equipment readily available. Monitor infusion during and after administration. Discontinue immediately and treat if anaphylaxis or hypersensitivity reactions occur. Pregnancy. Nursing mothers.

ANTHIM Classification:

Monoclonal antibody.

Adverse Reactions:

Headache, pruritus, infections of the upper respiratory tract, cough, vessel puncture site bruise, infusion site swelling, nasal congestion, infusion site pain, urticaria, pain in extremity.

Generic Drug Availability:

NO

How Supplied:

Single-dose vial (6mL)—1