• Fungal infections

Ancobon Generic Name & Formulations

General Description

Flucytosine 250mg, 500mg; caps.

Pharmacological Class


How Supplied


Generic Availability


Ancobon Indications


In combination with amphotericin B: Candida infections in septicemia, endocarditis, UTIs and pulmonary infections; cryptococcus infections in meningitis, pulmonary, septicemia, and UTIs.

Ancobon Dosage and Administration

Adults and Children

Usually 50–150mg/kg per day given in divided doses every 6hrs. To minimize GI upset, give a few capsules at a time over 15mins. Renal impairment: give initial dose at lower range.

Ancobon Contraindications


Known complete dihydropyrimidine dehydrogenase (DPD) enzyme deficiency.

Ancobon Boxed Warnings

Boxed Warning

Use extreme caution in patients with impaired renal function.

Ancobon Warnings/Precautions


Increased risk of severe drug toxicity in patients with DPD deficiency (see Contraindications). Consider discontinuing treatment if drug toxicity is suspected. Renal or hepatic impairment. Monitor electrolytes, blood count, renal and hepatic function before and during therapy. Bone marrow depression (eg, hematologic disease, history or currently treated with radiation or bone marrow depressants). Pregnancy. Nursing mothers: not recommended.

Ancobon Pharmacokinetics

See Literature

Ancobon Interactions


Antagonized by cytosine arabinoside. May be potentiated by drugs that impair glomerular filtration.

Ancobon Adverse Reactions

Adverse Reactions

Cardiac events, chest pain, dyspnea, GI upset, abdominal pain, hepatic dysfunction, elevated creatinine and BUN, blood dyscrasias, ataxia, headache, confusion, fatigue, hypoglycemia, hypokalemia, rash, allergic reactions, others.

Ancobon Clinical Trials

See Literature

Ancobon Note

Not Applicable

Ancobon Patient Counseling

See Literature