Inborn errors of metabolism:
Recent Updates:
Monograph added.
Indications for: AMVUTTRA
Polyneuropathy of hereditary transthyretin-mediated amyloidosis.
Adult Dosage:
Give by SC inj in abdomen, thighs, or upper arms. 25mg once every 3 months.
Children Dosage:
Not established.
AMVUTTRA Warnings/Precautions:
Supplement with recommended daily Vit. A allowance. Refer for eye exam if ocular symptoms of Vit. A deficiency occur (eg, night blindness). Moderate or severe hepatic impairment, severe renal impairment, or ESRD: not studied. Elderly. Pregnancy. Nursing mothers.
AMVUTTRA Classification:
Transthyretin-directed small interfering RNA.
Adverse Reactions:
Arthralgia, dyspnea, Vit. A decreased; inj site reactions, AV heart block.
Generic Drug Availability:
NO
How Supplied:
Single-dose prefilled syringe—1
Pricing for AMVUTTRA
0.5ml prefilled syringe of 25mg/0.5ml
carton
(Qty: 1)
Appx. price
$114302
