• Muscle spasms

Amrix Generic Name & Formulations

General Description

Cyclobenzaprine HCl 15mg, 30mg; ext-rel caps.

Pharmacological Class

Muscle relaxant (central).

How Supplied



Amrix Indications


Adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.

Amrix Dosage and Administration


Swallow whole; or may sprinkle contents on applesauce and swallow immediately without chewing. Take at same time each day. 15mg once daily; may increase to 30mg/day given once daily. Max 2–3 weeks.


Not established.

Amrix Contraindications


Acute post-MI. Arrhythmias, heart block, other conduction disturbances. CHF. Hyperthyroidism. During or within 14 days of MAOIs.

Amrix Boxed Warnings

Not Applicable

Amrix Warnings/Precautions


Not effective in treating spasticity associated with cerebral or spinal chord disease or in children with cerebral palsy. Consider discontinuing if significant CNS symptoms develop. Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Hepatic impairment or elderly: not recommended. Pregnancy. Nursing mothers.

Amrix Pharmacokinetics

See Literature

Amrix Interactions


See Contraindications. Hypertensive crisis with MAOIs. Increased risk of serotonin syndrome with other serotonergic drugs (eg, SSRIs, SNRIs, tricyclic antidepressants, tramadol, bupropion, meperidine, verapamil, MAOIs); discontinue if occurs. May potentiate alcohol, barbiturates, other CNS depressants. Caution with anticholinergics. May antagonize guanethidine and similar acting compounds. May enhance seizure risk with concomitant tramadol.

Amrix Adverse Reactions

Adverse Reactions

Dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, somnolence; serotonin syndrome, cardiovascular effects.

Amrix Clinical Trials

See Literature

Amrix Note

Not Applicable

Amrix Patient Counseling

See Literature