Multiple sclerosis:
Indications for AMPYRA:
To improve walking in patients with multiple sclerosis (demonstrated by an increase in walking speed).
Adult Dosage:
Swallow whole. ≥18yrs: max 10mg every 12hrs.
Children Dosage:
<18yrs: not established.
AMPYRA Contraindications:
History of seizures. Moderate or severe renal impairment (CrCl ≤50mL/min). Hypersensitivity to 4-aminopyridine.
AMPYRA Warnings/Precautions:
Assess renal function before initiation; monitor at least annually. Mild renal impairment (CrCl 51–80mL/min): increased risk of seizures. Discontinue if signs/symptoms of anaphylaxis occurs. Pregnancy. Nursing mothers.
AMPYRA Classification:
Potassium channel blocker.
AMPYRA Interactions:
Discontinue other forms of 4-aminopyridine prior to initiating. Concomitant OCT2 inhibitors (eg, cimetidine) may potentiate the risk of seizures.
Adverse Reactions:
UTI, insomnia, dizziness, headache, nausea, asthenia, back pain, balance disorder, MS relapse, paresthesia, nasopharyngitis, constipation, dyspepsia, throat pain; seizures (possible at higher doses), severe allergic reactions.
Generic Drug Availability:
YES
How Supplied:
Tabs—60
