Ampicillin Sodium Injection

  • Bacterial infections

Ampicillin Sodium Injection Generic Name & Formulations

General Description

Ampicillin sodium 125mg, 250mg, 500mg, 1g, 2g, 10g; per vial; pwd for IV or IM inj after reconstitution and dilution.

Pharmacological Class

Broad-spectrum penicillin.

How Supplied

Contact supplier.

Ampicillin Sodium Injection Indications


Ampicillin-sensitive infections.

Ampicillin Sodium Injection Dosage and Administration

Adults and Children

Give IV inj slowly over at least 10–15 minutes; rapid IV administration may result in convulsive seizures. Respiratory tract and soft tissue infections: <40kg: 25–50mg/kg per day in equally divided doses every 6–8 hours. ≥40kg: 250–500mg every 6 hours. GI or GU tract infections (including N. gonorrhoeae in women): <40kg: 50mg/kg per day in equally divided doses every 6–8 hours. ≥40kg: 500mg every 6 hours. Urethritis in males due to N. gonorrhoeae: two doses of 500mg each at interval of 8–12 hours. Meningitis: Initiate with IV drip, then continue IM. 150–200mg/kg per day in equally divided doses every 3–4 hours. Septicimia: Initiate IV for at least 3 days, then continue IM every 3–4 hours. 150–200mg/kg per day; treat for at least 10 days if caused by Group A β-hemolytic streptococci.

Ampicillin Sodium Injection Contraindications

Not Applicable

Ampicillin Sodium Injection Boxed Warnings

Not Applicable

Ampicillin Sodium Injection Warnings/Precautions


Cephalosporin, imipenem, other allergy or mononucleosis: not recommended. Monitor blood, renal, and liver function in long-term use. Pregnancy (Cat.B). Nursing mothers.

Ampicillin Sodium Injection Pharmacokinetics

See Literature

Ampicillin Sodium Injection Interactions


May cause false (+) glucose test with Clinitest, Benedict's or Fehling's soln. Potentiated by probenecid. May increase risk of rash with allopurinol.

Ampicillin Sodium Injection Adverse Reactions

Adverse Reactions

Anaphylaxis, urticaria, GI upset, blood dyscrasias.

Ampicillin Sodium Injection Clinical Trials

See Literature

Ampicillin Sodium Injection Note


Formerly known under the brand names Principen, Totacillin, Pfizerpen-A, Penbritin, Omnipen, Amcill (caps, susp); Polycillin-N, Totacillin-N, Penbritin-S, Omnipen-N (inj).

Ampicillin Sodium Injection Patient Counseling

See Literature