• Mood disorders

Amoxapine Generic Name & Formulations

General Description

Amoxapine 25mg, 50mg, 100mg, 150mg; tabs.

Pharmacological Class


How Supplied

Tabs 25mg, 50mg, 100mg—100; 150mg—30


Amoxapine Indications


Depression in patients with neurotic or reactive depressive disorders as well as endogenous and psychotic depressions. Depression accompanied by anxiety or agitation.

Amoxapine Dosage and Administration


Initially 50mg 2–3 times daily; may increase to 100mg 2–3 times daily by the end of the first week. May increase above 300mg/day if dose has been ineffective for a period of at least 2 weeks. Maintenance: when effective dosage established, may give as single dose at bedtime (max 300mg). Elderly: initially 25mg 2–3 times daily; may increase by the end of the first week to 50mg 2–3 times daily. May increase carefully up to 300mg/day if necessary.


Not recommended.

Amoxapine Contraindications


Within 14 days of MAOIs. During acute recovery phase following MI.

Amoxapine Boxed Warnings

Not Applicable

Amoxapine Warnings/Precautions


Monitor for clinical worsening, suicidality, and unusual changes in behavior, esp. during initial few months of treatment and during dose changes. Screen for bipolar disorder prior to initiating therapy. Urinary retention. Angle-closure glaucoma. Increased intraocular pressure. Cardiovascular disorders (monitor closely). Seizure disorders. Discontinue if rash, fever, tardive dyskinesia or neuroleptic malignant syndrome develop. Write ℞ for smallest practical amount. Pregnancy (Cat.C). Nursing mothers.

Amoxapine Pharmacokinetics

See Literature

Amoxapine Interactions


During or within 5 weeks of fluoxetine. Hyperpyretic crises, severe convulsions, and death with MAOIs (see Contraindications). Potentiates alcohol, barbiturates, other CNS depressants. Paralytic ileus with anticholinergics. Monitor serum levels with CYP450 2D6 inhibitors (eg, quinidine, cimetidine, phenothiazines, propafenone, flecainide, others: see literature). Caution with concomitant electroshock therapy.

Amoxapine Adverse Reactions

Adverse Reactions

Drowsiness, dry mouth, constipation, blurred vision, CNS effects (eg, anxiety, insomnia, restlessness, nervousness, palpitations, tremors, confusion, excitement, nightmares, ataxia, alterations in EEG patterns), edema, rash, elevated prolactin levels, nausea, dizziness, headache, fatigue, weakness, excessive appetite, increased perspiration.

Amoxapine Clinical Trials

See Literature

Amoxapine Note


Formerly known under the brand name Asendin.

Amoxapine Patient Counseling

See Literature