Amondys 45

  • Miscellaneous musculoskeletal disorders

Amondys 45 Generic Name & Formulations

General Description

Casimersen 50mg/mL; soln for IV infusion after dilution; preservative-free.

Pharmacological Class

Antisense oligonucleotide.

How Supplied

Single-dose vial (2mL)—1


Generic Availability


Amondys 45 Indications


Duchenne muscular dystrophy (DMD) in patients who have a confirmed mutation of the DMD gene that is amenable to exon 45 skipping.

Amondys 45 Dosage and Administration

Adults and Children

Give as IV infusion over 35–60mins. 30mg/kg once weekly.

Amondys 45 Contraindications

Not Applicable

Amondys 45 Boxed Warnings

Not Applicable

Amondys 45 Warnings/Precautions


Monitor renal function. Measure serum cystatin C, urine dipstick, and urine protein-to-creatinine ratio, and consider measuring GFR prior to initiation. During treatment, monitor urine dipstick monthly, and serum cystatin C and urine protein-to-creatinine ratio every 3 months. To test urine protein: may use urine samples obtained prior to infusion or at least 48hrs after the most recent infusion. Refer to pediatric nephrologist if a persistent increase in serum cystatin C or proteinuria is detected. Renal impairment: monitor closely. Pregnancy. Nursing mothers.

Amondys 45 Pharmacokinetics

See Literature

Amondys 45 Interactions


Do not mix or infuse with other drugs concomitantly via same IV access line. May cause false (+) results for urine protein with using pyrogallol red reagent.

Amondys 45 Adverse Reactions

Adverse Reactions

Upper RTI, cough, pyrexia, headache, arthralgia, oropharyngeal pain; renal toxicity.

Amondys 45 Clinical Trials

See Literature

Amondys 45 Note

Not Applicable

Amondys 45 Patient Counseling

See Literature