• Mood disorders

Amitriptyline Generic Name & Formulations

General Description

Amitriptyline HCl 10mg, 25mg, 50mg, 75mg, 100mg, 150mg; tabs.

Pharmacological Class


How Supplied

Contact supplier.

Amitriptyline Indications


Depression especially endogenous.

Amitriptyline Dosage and Administration


Initially 75mg daily in divided doses or 50–100mg daily at bedtime; max 150mg daily. Elderly and adolescents: reduce dose.


Not recommended.

Amitriptyline Contraindications


During or within 14 days of MAOIs. Acute post MI.

Amitriptyline Boxed Warnings

Not Applicable

Amitriptyline Warnings/Precautions


History of seizures, urinary retention, glaucoma. Cardiovascular disease. Suicidal tendencies. Surgery. ECT. Psychosis. Hyperthyroidism. Liver dysfunction. Diabetes. Gradually reduce to lowest effective maintenance dose. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Amitriptyline Pharmacokinetics

See Literature

Amitriptyline Interactions


During or within 5 weeks of fluoxetine. Hyperpyretic crises, severe convulsions, and death with MAOIs (see Contraindications). May block guanethidine. Potentiates alcohol, barbiturates, other CNS depressants. Delirium with disulfiram, ethchlorvynol. Paralytic ileus with anticholinergics. Hyperpyrexia with anticholinergics, sympathomimetics. Monitor serum levels with CYP450 inhibitors (eg, quinidine, cimetidine, phenothiazines, propafenone, flecainide, others: see literature).

Amitriptyline Adverse Reactions

Adverse Reactions

Drowsiness, anticholinergic effects, CNS overstimulation, arrhythmias, stroke, coma, confusion, extrapyramidal symptoms, hypo- or hypertension, nausea, fatigue, rash, increased perspiration, headache, photosensitivity, edema, blood dyscrasias, alopecia, libido changes, changes in blood sugar; women: breast enlargement, galactorrhea; men: testicular swelling, gynecomastia.

Amitriptyline Clinical Trials

See Literature

Amitriptyline Note


Formerly known under the brand name Elavil.

Amitriptyline Patient Counseling

See Literature