• Anesthetics

Amidate Generic Name & Formulations

General Description

Etomidate 2mg/mL; soln for IV inj.

Pharmacological Class


How Supplied

Vial—10mL, 20mL; Ampul—10mL, 20mL; Abboject syringe—20mL


Generic Availability


Amidate Indications


For the induction of general anesthesia. For the supplementation of subpotent anesthetic agents (eg, nitrous oxide in oxygen) during maintenance of anesthesia for short operative procedures (eg, dilation and curettage, cervical conization).

Amidate Dosage and Administration

Adults and Children

<10yrs: not recommended. Induction: Give by IV inj over 30–60 seconds. ≥10yrs: Individualize. Usual range: 0.2–0.6mg/kg. Usual dose: 0.3mg/kg. Elderly: may need to reduce dose. Supplementation: smaller increments may be given.

Amidate Contraindications

Not Applicable

Amidate Boxed Warnings

Not Applicable

Amidate Warnings/Precautions


To be administered only by those experienced in general anesthesia. May reduce plasma cortisol and aldosterone concentrations; consider exogenous replacement in patients undergoing severe stress. Pediatric neurotoxicity risk with repeated or prolonged use. Renal impairment. Elderly (may induce cardiac depression). Labor & delivery: not recommended. Pregnancy (Cat.C). Nursing mothers.

Amidate Pharmacokinetics

See Literature

Amidate Interactions


Concomitant IV fentanyl and other neuroactive drugs; may need to adjust etomidate dose.

Amidate Adverse Reactions

Adverse Reactions

Transient venous pain on inj, transient skeletal muscle movements including myoclonus, hyper- or hypoventilation, apnea, laryngospasm, hiccup, snoring, hyper- or hypotension, tachycardia, arrhythmias, post-op nausea/vomiting.

Amidate Clinical Trials

See Literature

Amidate Note

Not Applicable

Amidate Patient Counseling

See Literature