Amantadine Syrup Generic Name & Formulations
Amantadine HCl 50mg/5mL; raspberry flavor.
Amantadine Syrup Indications
Parkinsonism. Drug-induced extrapyramidal reactions.
Amantadine Syrup Dosage and Administration
Parkinsonism monotherapy: initially 100mg twice daily, may increase after 1–2 weeks by 100mg daily. Serious associated illness or high doses of other antiparkinson drugs: 100mg once daily, may increase after 1 to several weeks to 100mg twice daily; max 400mg/day in divided doses. Extrapyramidal disorders: 100mg twice daily; max 300mg/day in divided doses. Renal dysfunction: reduce dose; see literature.
Amantadine Syrup Contraindications
Amantadine Syrup Boxed Warnings
Amantadine Syrup Warnings/Precautions
Adjust dose gradually. History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.
Amantadine Syrup Pharmacokinetics
Amantadine Syrup Interactions
Caution with CNS stimulants. Thioridazine may worsen tremor in elderly patients with parkinsonism.
Amantadine Syrup Adverse Reactions
Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue.
Amantadine Syrup Clinical Trials
Amantadine Syrup Note
Formerly known under the brand name Symmetrel.
Amantadine Syrup Patient Counseling