Select therapeutic use:

Parkinsonism:

Indications for Amantadine HCl Syrup:

Parkinsonism. Drug-induced extrapyramidal reactions.

Adult:

Parkinsonism monotherapy: initially 100mg twice daily, may increase after 1–2 weeks by 100mg daily. Serious associated illness or high doses of other antiparkinson drugs: 100mg once daily, may increase after 1 to several weeks to 100mg twice daily; max 400mg/day in divided doses. Extrapyramidal disorders: 100mg twice daily; max 300mg/day in divided doses. Renal dysfunction: reduce dose; see literature.

Children:

Not recommended.

Warnings/Precautions:

Adjust dose gradually. History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Dopamine agonist.

Interactions:

Caution with CNS stimulants. Thioridazine may worsen tremor in elderly patients with parkinsonism.

Adverse Reactions:

Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue.

Note:

Formerly known under the brand name Symmetrel.

How Supplied:

Contact supplier.

Viral infections:

Indications for Amantadine HCl Syrup:

Prophylaxis and treatment of influenza A infections.

Adult:

200mg daily in 1–2 divided doses. Elderly: 100mg/day. Renal dysfunction: reduce dose; see literature.

Children:

<1yr: not recommended. 1–9yrs: 4.4–8.8mg/kg per day; max 150mg daily. 9–12yrs: 100mg twice daily. Renal dysfunction: reduce dose; see literature.

Warnings/Precautions:

History of seizures. Heart failure. Orthostatic hypotension. Peripheral edema. Renal (CrCl <50mL/min) or hepatic dysfunction. Psychiatric disorders. Suicidal ideation. History of recurrent eczematoid rash. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Pharmacologic Class:

Adamantane.

Interactions:

Caution with CNS stimulants.

Adverse Reactions:

Neuroleptic malignant syndrome (when drug is withdrawn or dose is reduced), nausea, dizziness, insomnia, heart failure, anxiety, irritability, hallucinations, confusion, anorexia, anticholinergic effects, constipation, ataxia, livedo reticularis, peripheral edema, orthostatic hypotension, headache, somnolence, dream abnormality, diarrhea, fatigue.

Note:

Formerly known under the brand name Symmetrel.

How Supplied:

Contact supplier.