Aleve Pm

  • Sleep-wake disorders

Aleve Pm Generic Name & Formulations

General Description

Naproxen sodium 220mg, diphenhydramine HCl 25mg; caplets.

Pharmacological Class

NSAID + hypnotic (anticholinergic).

How Supplied

Caplets—20, 50, 80, 120


Aleve Pm Indications


Relief of occasional sleeplessness when associated with minor aches and pains.

Aleve Pm Dosage and Administration


Take with fluids. 2 caplets at bedtime. Max 2 caplets/24hrs.


<12yrs: not recommended.

Aleve Pm Contraindications


Aspirin allergy. Unless sufficient time for a full night's sleep. Immediately before or after cardiac surgery. Sleeplessness without pain. Concomitant with other diphenhydramine-containing products (including topicals).

Aleve Pm Boxed Warnings

Not Applicable

Aleve Pm Warnings/Precautions


Increased risk of severe stomach bleeding (esp. ≥60yrs old). History of GI disorders (eg, heartburn, bleeding ulcers). Respiratory disorders (eg, emphysema, bronchitis). Increased risk of heart attack or failure, and stroke. Hypertension. Heart disease. Recent stroke. Liver cirrhosis. Renal disease. Asthma. Glaucoma. GI or urinary obstruction. Reevaluate if pain worsens or lasts >10 days or sleeplessness persists continuously >2 weeks. Elderly. Pregnancy (esp. during ≥20 weeks): not recommended. Nursing mothers.

Aleve Pm Pharmacokinetics

See Literature

Aleve Pm Interactions


Avoid concomitant other pain relievers. Naproxen may decrease effects of aspirin. Increased risk of GI bleed with anticoagulants, corticosteroids, other OTC or Rx NSAID-containing products (eg, ibuprofen, naproxen, others), ≥3 alcoholic drinks/day, or prolonged use. Caution with diuretics. Additive effects with other antihistamines, anticholinergics, sedatives, tranquilizers, or any other sleep-aid.

Aleve Pm Adverse Reactions

Adverse Reactions

Drowsiness, GI upset/bleed, vomit blood, feel faint, rash, redness, difficulty swallowing, symptoms of heart problems or stroke (eg, trouble breathing, chest pain, weakness, slurred speech, leg swelling), allergic reactions; discontinue if occur.

Aleve Pm Clinical Trials

See Literature

Aleve Pm Note

Not Applicable

Aleve Pm Patient Counseling

See Literature