• Nausea

Akynzeo Generic Name & Formulations

General Description

Netupitant, palonosetron (as HCl); 300mg/0.5mg; hard gel caps.

Pharmacological Class

Substance P/NK1 receptor antagonist + 5-HT3 receptor antagonist.

How Supplied

Tabs—1, 4; Single-dose vials (pwd or soln)—1

Generic Availability


Akynzeo Indications


Prevention of acute and delayed nausea and vomiting due to initial and repeat courses of chemotherapy, including highly emetogenic chemotherapy.

Akynzeo Dosage and Administration


≥18yrs: Highly emetogenic chemotherapy (including cisplatin-based): 1 cap approx. 1hr prior to chemotherapy with oral dexamethasone 12mg given 30mins before chemotherapy on Day 1, then 8mg orally once daily on Days 2–4. Anthracyclines and cyclophosphamide-based chemotherapy, or non-highly emetogenic chemotherapy: 1 cap approx. 1hr prior to chemotherapy with oral dexamethasone 12mg given 30mins prior to chemotherapy on Day 1.


<18yrs: not established.

Akynzeo Contraindications

Not Applicable

Akynzeo Boxed Warnings

Not Applicable

Akynzeo Warnings/Precautions


Monitor for symptoms of serotonin syndrome; discontinue and treat if occurs. Severe hepatic or renal impairment, ESRD: avoid. Elderly. Pregnancy. Nursing mothers.

Akynzeo Pharmacokinetics

See Literature

Akynzeo Interactions


Increased risk of serotonin syndrome with concomitant other serotonergic drugs (eg, SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue). May potentiate CYP3A4 substrates (eg, dexamethasone [use reduced dose], midazolam, alprazolam, triazolam, docetaxel, paclitaxel, etoposide, irinotecan, cyclophosphamide, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine); caution and monitor. Avoid concomitant strong CYP3A4 inducers (eg, rifampin). Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). Concomitant warfarin: monitor INR and adjust dose as needed. Inj: incompatible with divalent cation-containing solutions, Lactated Ringer's Injection, Hartmann's Solution.

Akynzeo Adverse Reactions

Adverse Reactions

Headache, asthenia, dyspepsia, fatigue, constipation, erythema; hypersensitivity reactions.

Akynzeo Clinical Trials

See Literature

Akynzeo Note

Not Applicable

Akynzeo Patient Counseling

See Literature