Akynzeo Injection Generic Name & Formulations
Fosnetupitant, palonosetron; 235mg/0.25mg/20mL; per vial; soln for IV infusion after dilution; preservative-free.
Substance P/NK1 receptor antagonist + 5-HT3 receptor antagonist.
Tabs—1, 4; Single-dose vials (pwd or soln)—1
Akynzeo Injection Indications
Prevention of acute and delayed nausea and vomiting due to initial and repeat courses of highly emetogenic chemotherapy.
Limitations of Use
Not studied for prevention of nausea and vomiting associated with anthracycline plus cyclophosphamide chemotherapy.
Akynzeo Injection Dosage and Administration
Infuse over 30mins. ≥18yrs: Highly emetogenic chemotherapy (including cisplatin-based): 1 vial approx. 30mins prior to chemotherapy with oral dexamethasone 12mg given 30mins before chemotherapy on Day 1, then 8mg orally once daily on Days 2–4.
<18yrs: not established.
Akynzeo Injection Contraindications
Akynzeo Injection Boxed Warnings
Akynzeo Injection Warnings/Precautions
Monitor for symptoms of serotonin syndrome; discontinue and treat if occurs. Severe hepatic or renal impairment, ESRD: avoid. Elderly. Pregnancy. Nursing mothers.
Akynzeo Injection Pharmacokinetics
Akynzeo Injection Interactions
Increased risk of serotonin syndrome with concomitant other serotonergic drugs (eg, SSRIs, SNRIs, MAOIs, mirtazapine, fentanyl, lithium, tramadol, IV methylene blue). May potentiate CYP3A4 substrates (eg, dexamethasone [use reduced dose], midazolam, alprazolam, triazolam, docetaxel, paclitaxel, etoposide, irinotecan, cyclophosphamide, ifosfamide, imatinib, vinorelbine, vinblastine, vincristine); caution and monitor. Avoid concomitant strong CYP3A4 inducers (eg, rifampin). Potentiated by strong CYP3A4 inhibitors (eg, ketoconazole). Concomitant warfarin: monitor INR and adjust dose as needed. Inj: incompatible with divalent cation-containing solutions, Lactated Ringer's Injection, Hartmann's Solution.
Akynzeo Injection Adverse Reactions
Headache, asthenia, dyspepsia, fatigue, constipation, erythema; hypersensitivity reactions.
Akynzeo Injection Clinical Trials
Akynzeo Injection Note
Akynzeo Injection Patient Counseling