Akovaz Generic Name & Formulations
Ephedrine sulfate 50mg/mL (must be diluted); 25mg/5mL (premixed); soln for IV bolus.
Single-dose vials (50mg/mL)—25; Single-dose prefilled syringes (25mg/5mL)—10
Treatment of clinically important hypotension occurring in the setting of anesthesia.
Akovaz Dosage and Administration
Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg. Adjust dosage based on blood pressure goal.
Akovaz Boxed Warnings
Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.
Severe postpartum hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blocker; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.
Akovaz Adverse Reactions
Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, dizziness, restlessness.
Akovaz Clinical Trials
Akovaz Patient Counseling