• Anesthetics

Akovaz Generic Name & Formulations

General Description

Ephedrine sulfate 50mg/mL (must be diluted); 25mg/5mL (premixed); soln for IV bolus.

Pharmacological Class


How Supplied

Single-dose vials (50mg/mL)—25; Single-dose prefilled syringes (25mg/5mL)—10


Generic Availability


Akovaz Indications


Treatment of clinically important hypotension occurring in the setting of anesthesia.

Akovaz Dosage and Administration


Give as IV bolus. Initially 5–10mg, may repeat as needed; max total dose: 50mg. Adjust dosage based on blood pressure goal.


Not established.

Akovaz Contraindications

Not Applicable

Akovaz Boxed Warnings

Not Applicable

Akovaz Warnings/Precautions


Tolerance may develop. Repeated doses may cause tachyphylaxis. Have alternative pressor agent readily available. Hypertension. Renal impairment: monitor. Elderly. Pregnancy. Nursing mothers.

Akovaz Pharmacokinetics

See Literature

Akovaz Interactions


Severe postpartum hypertension with concomitant oxytocics (eg, methylergonovine, ergonovine); monitor. Potentiated by MAOIs, clonidine, propofol, atropine; monitor. Antagonized by alpha-blockers, beta-blockers, reserpine, quinidine, mephentermine; monitor. May inhibit hypotensive effect of guanethidine; monitor and adjust dose. May reduce onset time of neuromuscular blockade when used for intubation with rocuronium if used simultaneously. May decrease efficacy of epidural blocker; monitor. Concomitant theophylline may increase frequency of nausea, nervousness, insomnia. Concomitant digitalis glycosides may cause cardiac arrhythmias; monitor.

Akovaz Adverse Reactions

Adverse Reactions

Nausea, vomiting, tachycardia, palpitations, reactive hypertension, bradycardia, ventricular ectopics, dizziness, restlessness.

Akovaz Clinical Trials

See Literature

Akovaz Note

Not Applicable

Akovaz Patient Counseling

See Literature