Advil Pm Liqui-gels

  • Sleep-wake disorders

Advil Pm Liqui-gels Generic Name & Formulations

General Description

Ibuprofen (solubilized) 200mg, diphenhydramine HCl 25mg.

Pharmacological Class

NSAID + hypnotic (anticholinergic).

See Also

How Supplied

Caplets—2, 20, 40, 80, 120 (orig or EZ open), 200; Liqui-Gels—20, 40, 80

Advil Pm Liqui-gels Indications


Relief of occasional sleeplessness when associated with minor aches and pains.

Advil Pm Liqui-gels Dosage and Administration


2 caplets or liqui-gels at bedtime. Max 2 caplets or liqui-gels/24hrs.


<12yrs: not recommended.

Advil Pm Liqui-gels Contraindications


Aspirin allergy. Unless sufficient time for a full night's sleep. Immediately before or after cardiac surgery. Sleeplessness without pain. Concomitant with other diphenhydramine-containing products (including topicals).

Advil Pm Liqui-gels Boxed Warnings

Not Applicable

Advil Pm Liqui-gels Warnings/Precautions


Increased risk of severe stomach bleeding (esp. ≥60yrs old). History of GI disorders (eg, heartburn, bleeding ulcers). Respiratory disorders (eg, emphysema, bronchitis). Increased risk of heart attack or failure, and stroke. Hypertension. Heart disease. Recent stroke. Liver cirrhosis. Renal disease. Asthma. Glaucoma. GI or urinary obstruction. Reevaluate if pain persists or worsens after >10 days or sleeplessness persists continuously >2 weeks. Elderly. Pregnancy (esp. during ≥20 weeks): not recommended. Nursing mothers.

Advil Pm Liqui-gels Pharmacokinetics

See Literature

Advil Pm Liqui-gels Interactions


Avoid aspirin or other pain relievers. Increased risk of GI bleed with anticoagulants, corticosteroids, other OTC or Rx NSAID-containing products (eg, ibuprofen, naproxen, others), ≥3 alcoholic drinks/day, or prolonged use. Caution with diuretics. Additive effects with other antihistamines, anticholinergics, sedatives, tranquilizers, or any other sleep-aid.

Advil Pm Liqui-gels Adverse Reactions

Adverse Reactions

Drowsiness, GI upset/bleed, rash, symptoms of heart problems or stroke (eg, trouble breathing, feel faint, slurred speech), redness, swelling, allergic reactions; discontinue if occur.

Advil Pm Liqui-gels Clinical Trials

See Literature

Advil Pm Liqui-gels Note

Not Applicable

Advil Pm Liqui-gels Patient Counseling

See Literature