Obesity:

Indications for: ADIPEX-P

A short-term (a few weeks) adjunct in a regimen of weight reduction based on exercise, behavioral modification and caloric restriction in the management of exogenous obesity for patients with an initial body mass index ≥30kg/m2, or ≥27kg/m2 in the presence of other risk factors (eg, hypertension, diabetes, hyperlipidemia).

Adult Dosage:

>16yrs: Individualize. Usual dose: 37.5mg once daily before or 1–2 hrs after breakfast, or 18.75mg 1–2 times daily. Avoid late evening dosing. Severe renal impairment (eGFR 15–29mL/min/1.73m2): max 15mg daily.

Children Dosage:

≤16yrs: not recommended.

ADIPEX-P Contraindications:

History of cardiovascular disease (eg, coronary artery disease, stroke, arrhythmias, congestive heart failure, uncontrolled hypertension). Hyperthyroidism. Glaucoma. Agitated states. History of drug abuse. Pregnancy. Nursing. During or within 14 days of MAOIs.

ADIPEX-P Warnings/Precautions:

Increased risk of primary pulmonary hypertension, valvular heart disease. Discontinue if unexplained dyspnea, angina, syncope, or lower extremity edema develops. Discontinue if tolerance to the anorectant effect develops. Mild hypertension. Diabetes. Prescribe minimal supply to avoid overdose. Renal impairment (eGFR <15mL/min/1.73m2), including ESRD requiring dialysis: avoid. Elderly.

ADIPEX-P Classification:

Sympathomimetic.

ADIPEX-P Interactions:

See Contraindications. Hypertensive crisis possible with MAOIs. Concomitant weight loss drugs, including SSRIs (fluoxetine, sertraline, fluvoxamine, paroxetine), OTC and herbal products: not recommended. Caution with alcohol. Insulin or oral hypoglycemic medications requirements may be altered. May decrease hypotensive effect of adrenergic neuron blocking drugs.

Adverse Reactions:

Primary pulmonary hypertension, regurgitant cardiac valvular disease, palpitation, tachycardia, elevated blood pressure, ischemic events, overstimulation, restlessness, dizziness, insomnia, euphoria, dysphoria, tremor, headache, dry mouth, unpleasant taste, GI upset, constipation, urticaria, impotence, changes in libido; rare: psychotic episodes.

Generic Drug Availability:

YES

How Supplied:

Caps—100; Tabs—30, 100